Articles Reviewed |
| 1. D C Otero et al. Cd19-dependent activation of Akt kinase in B-lymphocytes. 2001 |
| 2. M J Rane et al. p38 Kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils. 2001 |
| 3. K Hisamoto et al. Estrogen induces the Akt-dependent activation of endothelial nitric-oxide synthase in vascular endothelial cells. 2001 |
| 4. R A Campbell et al. Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance. 2001 |
| 5. T Wada et al. Overexpression of SH2-containing inositol phosphatase 2 results in negative regulation of insulin-induced metabolic actions in 3T3-L1 adipocytes via its 5'-phosphatase catalytic activity. 2001 |
| 6. A L Sirén et al. Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress. 2001 |
| 7. M Zang et al. Microtubule integrity regulates Pak leading to Ras-independent activation of Raf-1. insights into mechanisms of Raf-1 activation. 2001 |
| 8. E Asselin et al. XIAP regulates Akt activity and caspase-3-dependent cleavage during cisplatin-induced apoptosis in human ovarian epithelial cancer cells. 2001 |
| 9. C Sweeney et al. Growth factor-specific signaling pathway stimulation and gene expression mediated by ErbB receptors. 2001 |
| 10. C Jiang et al. Caspases as key executors of methyl selenium-induced apoptosis (anoikis) of DU-145 prostate cancer cells. 2001 |
| 11. X Pesesse et al. The Src homology 2 domain containing inositol 5-phosphatase SHIP2 is recruited to the epidermal growth factor (EGF) receptor and dephosphorylates phosphatidylinositol 3,4,5-trisphosphate in EGF-stimulated COS-7 cells. 2001 |
| 12. D Camper-Kirby et al. Myocardial Akt activation and gender: increased nuclear activity in females versus males. 2001 |
| 13. E Avota et al. Disruption of Akt kinase activation is important for immunosuppression induced by measles virus. 2001 |
| 14. I Fleming et al. Phosphorylation of Thr(495) regulates Ca(2+)/calmodulin-dependent endothelial nitric oxide synthase activity. 2001 |
| 15. Y Sasaki et al. Involvement of Hgs/Hrs in signaling for cytokine-mediated c-fos induction through interaction with TAK1 and Pak1. 2001 |
| 16. S Fan et al. The multisubstrate adapter Gab1 regulates hepatocyte growth factor (scatter factor)-c-Met signaling for cell survival and DNA repair. 2001 |
| 17. H Huang et al. PTEN induces chemosensitivity in PTEN-mutated prostate cancer cells by suppression of Bcl-2 expression. 2001 |
| 18. K Yu et al. mTOR, a novel target in breast cancer: the effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer. 2001 |
| 19. Shyra Gardai et al. Activation of SHIP by NADPH oxidase-stimulated Lyn leads to enhanced apoptosis in neutrophils. 2002 |
| 20. Veronique Béréziat et al. Inhibition of insulin receptor catalytic activity by the molecular adapter Grb14. 2002 |
| 21. Russell D Klein et al. Black tea polyphenols inhibit IGF-I-induced signaling through Akt in normal prostate epithelial cells and Du145 prostate carcinoma cells. 2002 |
| 22. Fei Su et al. WISP-1 attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. 2002 |
| 23. Maria Diakonova et al. SH2-Bbeta is a Rac-binding protein that regulates cell motility. 2002 |
| 24. Thomas Jahn et al. Role for the adaptor protein Grb10 in the activation of Akt. 2002 |
| 25. Michael Mildner et al. Hepatocyte growth factor/scatter factor inhibits UVB-induced apoptosis of human keratinocytes but not of keratinocyte-derived cell lines via the phosphatidylinositol 3-kinase/AKT pathway. 2002 |
| 26. Toshifumi Fukuda et al. Novel mechanism of regulation of Rac activity and lamellipodia formation by RET tyrosine kinase. 2002 |
| 27. Armelle Yart et al. A function for phosphoinositide 3-kinase beta lipid products in coupling beta gamma to Ras activation in response to lysophosphatidic acid. 2002 |
| 28. Hong Wang et al. DNA mismatch repair deficiency accelerates endometrial tumorigenesis in Pten heterozygous mice. 2002 |
| 29. Shazli N Malik et al. Immunohistochemical demonstration of phospho-Akt in high Gleason grade prostate cancer. 2002 |
| 30. Bernardo Yusta et al. Glucagon-like peptide-2 receptor activation engages bad and glycogen synthase kinase-3 in a protein kinase A-dependent manner and prevents apoptosis following inhibition of phosphatidylinositol 3-kinase. 2002 |
| 31. Henri H Versteeg et al. VIIa/tissue factor interaction results in a tissue factor cytoplasmic domain-independent activation of protein synthesis, p70, and p90 S6 kinase phosphorylation. 2002 |
| 32. Christopher J Howe et al. Participation of the calcium/calmodulin-dependent kinases in hydrogen peroxide-induced Ikappa B phosphorylation in human T lymphocytes. 2002 |
| 33. Diana Birle et al. Negative feedback regulation of the tumor suppressor PTEN by phosphoinositide-induced serine phosphorylation. 2002 |
| 34. Hideki Murakami et al. Role of Dok1 in cell signaling mediated by RET tyrosine kinase. 2002 |
| 35. Mihail S Iordanov et al. The UV (Ribotoxic) stress response of human keratinocytes involves the unexpected uncoupling of the Ras-extracellular signal-regulated kinase signaling cascade from the activated epidermal growth factor receptor. 2002 |
| 36. Ming-Hui Zou et al. Modulation by peroxynitrite of Akt- and AMP-activated kinase-dependent Ser1179 phosphorylation of endothelial nitric oxide synthase. 2002 |
| 37. Giuseppe Pandini et al. Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved. 2002 |
| 38. Saori Sato et al. Regulation of kinase activity of 3-phosphoinositide-dependent protein kinase-1 by binding to 14-3-3. 2002 |
| 39. Anjana Saxena et al. Phosphoinositide binding by the pleckstrin homology domains of Ipl and Tih1. 2002 |
| 40. Heidi L Kenerson et al. Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors. 2002 |
| 41. Monique C A Duyndam et al. Evidence for a role of p38 kinase in hypoxia-inducible factor 1-independent induction of vascular endothelial growth factor expression by sodium arsenite. 2003 |
| 42. Joseph J Senn et al. Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes. 2003 |
| 43. DiAnna L Hynds et al. Rit promotes MEK-independent neurite branching in human neuroblastoma cells. 2003 |
| 44. Nobuo Noshita et al. Copper-zinc superoxide dismutase affects Akt activation after transient focal cerebral ischemia in mice. 2003 |
| 45. Weidong Wu et al. Zinc-induced PTEN protein degradation through the proteasome pathway in human airway epithelial cells. 2003 |
| 46. Lilly Y W Bourguignon et al. Hyaluronan-mediated CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and phosphatidylinositol 3-kinase signaling leading to cytokine (macrophage-colony stimulating factor) production and breast tumor progressio. 2003 |
| 47. Albert H Kim et al. JNK-interacting protein 1 promotes Akt1 activation. 2003 |
| 48. Yuichi Oike et al. Angiopoietin-related growth factor (AGF) promotes epidermal proliferation, remodeling, and regeneration. 2003 |
| 49. Ralf Benndorf et al. Angiotensin II type 2 receptor inhibits vascular endothelial growth factor-induced migration and in vitro tube formation of human endothelial cells. 2003 |
| 50. Hiroki Kuniyasu et al. Production of interleukin 15 by human colon cancer cells is associated with induction of mucosal hyperplasia, angiogenesis, and metastasis. 2003 |
| 51. Cynthia M Grimsley et al. Dock180 and ELMO1 proteins cooperate to promote evolutionarily conserved Rac-dependent cell migration. 2004 |
| 52. Atsushi Saito et al. Neuroprotective role of a proline-rich Akt substrate in apoptotic neuronal cell death after stroke: relationships with nerve growth factor. 2004 |
| 53. Karen L Wu et al. The NHE1 Na+/H+ exchanger recruits ezrin/radixin/moesin proteins to regulate Akt-dependent cell survival. 2004 |
| 54. P Christian Schulze et al. Hyperglycemia promotes oxidative stress through inhibition of thioredoxin function by thioredoxin-interacting protein. 2004 |
| 55. Hong Xia et al. Focal adhesion kinase is upstream of phosphatidylinositol 3-kinase/Akt in regulating fibroblast survival in response to contraction of type I collagen matrices via a beta 1 integrin viability signaling pathway. 2004 |
| 56. Weiya Xia et al. Phosphorylation/cytoplasmic localization of p21Cip1/WAF1 is associated with HER2/neu overexpression and provides a novel combination predictor for poor prognosis in breast cancer patients. 2004 |
| 57. Joao T Barata et al. Activation of PI3K is indispensable for interleukin 7-mediated viability, proliferation, glucose use, and growth of T cell acute lymphoblastic leukemia cells. 2004 |
| 58. Hitoshi Ogawa et al. Mechanisms of MAdCAM-1 gene expression in human intestinal microvascular endothelial cells. 2005 |
| 59. Filippo Acconcia et al. Palmitoylation-dependent estrogen receptor alpha membrane localization: regulation by 17beta-estradiol. 2005 |
| 60. Xiao-Feng Le et al. Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling. 2005 |
| 61. Stefan Kippenberger et al. Mechanical stretch stimulates protein kinase B/Akt phosphorylation in epidermal cells via angiotensin II type 1 receptor and epidermal growth factor receptor. 2005 |
| 62. Chaitali Basak et al. NF-kappaB- and C/EBPbeta-driven interleukin-1beta gene expression and PAK1-mediated caspase-1 activation play essential roles in interleukin-1beta release from Helicobacter pylori lipopolysaccharide-stimulated macrophages. 2005 |
| 63. Kohsuke Kanekura et al. A Rac1/phosphatidylinositol 3-kinase/Akt3 anti-apoptotic pathway, triggered by AlsinLF, the product of the ALS2 gene, antagonizes Cu/Zn-superoxide dismutase (SOD1) mutant-induced motoneuronal cell death. 2005 |
| 64. Michael N Corradetti et al. The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway. 2005 |
| 65. Hee Yun et al. Glucose deprivation increases mRNA stability of vascular endothelial growth factor through activation of AMP-activated protein kinase in DU145 prostate carcinoma. 2005 |
| 66. Zheng-Gen Jin et al. Flow shear stress stimulates Gab1 tyrosine phosphorylation to mediate protein kinase B and endothelial nitric-oxide synthase activation in endothelial cells. 2005 |
| 67. Ilchung Shin et al. H-Ras-specific activation of Rac-MKK3/6-p38 pathway: its critical role in invasion and migration of breast epithelial cells. 2005 |
| 68. Kip M Connor et al. Mitochondrial H2O2 regulates the angiogenic phenotype via PTEN oxidation. 2005 |
| 69. Susanne Urschel et al. Phosphorylation of grb10 regulates its interaction with 14-3-3. 2005 |
| 70. Jean S Campbell et al. Platelet-derived growth factor C induces liver fibrosis, steatosis, and hepatocellular carcinoma. 2005 |
| 71. Laura Suomalainen et al. Sphingosine-1-phosphate inhibits nuclear factor kappaB activation and germ cell apoptosis in the human testis independently of its receptors. 2005 |
| 72. Rinat Arbel-Goren et al. Cyclin-dependent kinase inhibitors and JNK act as molecular switches, regulating the choice between growth arrest and apoptosis induced by galectin-8. 2005 |
| 73. Eijiro Yamada et al. Akt2 phosphorylates Synip to regulate docking and fusion of GLUT4-containing vesicles. 2005 |
| 74. Konstantinos G Drosopoulos et al. Transformation by oncogenic RAS sensitizes human colon cells to TRAIL-induced apoptosis by up-regulating death receptor 4 and death receptor 5 through a MEK-dependent pathway. 2005 |
| 75. Minsub Shim et al. Protein kinase C-dependent regulation of NAG-1/placental bone morphogenic protein/MIC-1 expression in LNCaP prostate carcinoma cells. 2005 |
| 76. Roderick J Phillips et al. Epidermal growth factor and hypoxia-induced expression of CXC chemokine receptor 4 on non-small cell lung cancer cells is regulated by the phosphatidylinositol 3-kinase/PTEN/AKT/mammalian target of rapamycin signaling pathway and activation of hypoxia ind. 2005 |
| 77. Ju-Eun Oh et al. Beta ig-h3 induces keratinocyte differentiation via modulation of involucrin and transglutaminase expression through the integrin alpha3beta1 and the phosphatidylinositol 3-kinase/Akt signaling pathway. 2005 |
| 78. Loredana Moro et al. Down-regulation of BRCA2 expression by collagen type I promotes prostate cancer cell proliferation. 2005 |
| 79. Federico Cappuzzo et al. Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer. 2005 |
| 80. Marina K Holz et al. Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase. 2005 |
| 81. Richard Seonghun Nho et al. Role of integrin-linked kinase in regulating phosphorylation of Akt and fibroblast survival in type I collagen matrices through a beta1 integrin viability signaling pathway. 2005 |
| 82. Satoshi Nozawa et al. Inhibition of platelet-derived growth factor-induced cell growth signaling by a short interfering RNA for EWS-Fli1 via down-regulation of phospholipase D2 in Ewing sarcoma cells. 2005 |
| 83. Ye Zhou et al. Formylpeptide receptor FPR and the rapid growth of malignant human gliomas. 2005 |
| 84. Zhen Xu et al. Molecular dissection of PINCH-1 reveals a mechanism of coupling and uncoupling of cell shape modulation and survival. 2005 |
| 85. Jean-François Lavoie et al. TrkA induces apoptosis of neuroblastoma cells and does so via a p53-dependent mechanism. 2005 |
| 86. Margrit Hollborn et al. Changes in retinal gene expression in proliferative vitreoretinopathy: glial cell expression of HB-EGF. 2005 |
| 87. Annett Hahn-Windgassen et al. Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity. 2005 |
| 88. Yen-Chung Chen et al. Overexpression of NBS1 contributes to transformation through the activation of phosphatidylinositol 3-kinase/Akt. 2005 |
| 89. Elizabeth L Tudor et al. ALS2/Alsin regulates Rac-PAK signaling and neurite outgrowth. 2005 |
| 90. John R Basile et al. Semaphorin 4D/plexin-B1 induces endothelial cell migration through the activation of PYK2, Src, and the phosphatidylinositol 3-kinase-Akt pathway. 2005 |
| 91. Cheng Zhang et al. PTEN represses RNA Polymerase I transcription by disrupting the SL1 complex. 2005 |
| 92. Guillaume Bossis et al. Down-regulation of c-Fos/c-Jun AP-1 dimer activity by sumoylation. 2005 |
| 93. Yan Xing et al. Protein phosphatase subunit G5PR is needed for inhibition of B cell receptor-induced apoptosis. 2005 |
| 94. Takahiro Nobukuni et al. Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase. 2005 |
| 95. Kin Yip Lo et al. SLAM-associated protein as a potential negative regulator in Trk signaling. 2005 |
| 96. Bruno Canguilhem et al. RhoB protects human keratinocytes from UVB-induced apoptosis through epidermal growth factor receptor signaling. 2005 |
| 97. Yi Qin et al. The mammalian Scribble polarity protein regulates epithelial cell adhesion and migration through E-cadherin. 2005 |
| 98. Sylvia Major et al. AbMiner: a bioinformatic resource on available monoclonal antibodies and corresponding gene identifiers for genomic, proteomic, and immunologic studies. 2006 |
| 99. A Persson et al. A human protein atlas based on antibody proteomics. 2006 |