ABDSEROTEC search AbDSerotec APP products
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| ih | | Serotec APP antibody was tested in immunohistochemistry by HPA (HPA001462) . |
CELL SIGNALING TECHNOLOGY search Cell Signaling Technology APP products
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| ic, wb | | Cell Signaling Technology rabbit anti-phospho-APP antibody was used in western blot and immunocytochemistry to detect phospho-APP in CAD cells and mouse cortical neurons, COS-1, MDCK, and bovine aortic endothelial (BAEC) cells. |
| wb | | Cell Signaling Technology rabbit anti-APP antibody was used in western blot to study the coordinated transport of phosphorylated amyloid-beta precursor protein and c-Jun NH2-terminal kinase-interacting protein-1. |
SIGMA-ALDRICH search Sigma-Aldrich APP products
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| ih | | Sigma rabbit polyclonal anti-Amyloid Peptide β antibody (A1976) was used in tissue sections from human brain and in immunohistochemistry to study the expression of serotonin 5-HT2A and 5-HT6 receptors in the prefrontal cortex of Alzheimer and normal aging patients. |
| ih | | Sigma APP antibody was tested in immunohistochemistry by Human Protein Atlas. |
| ip, wb | | Sigma anti-APP-CTF antibody (A8717) was used in human cells and in western blot, immunoprecipitation to study the role for ubiquilin 1 in modulating amyloid precursor protein trafficking and Abeta secretion. |
| wb | | Sigma anti-APP 6E10 antibody was used in western blot to study the pathway for platelet-derived growth factor to induce the beta-gamma-secretase-mediated cleavage of alzheimer's amyloid precursor protein. |
| wb | | Sigma polyclonal anti-C terminus of APP antibody was used in human embryonic kidney 293 cells and in western blot to study the effect of presenilin 1 mutations on gamma42-secretase and epsilon-secretase cleavage of amyloid precursor protein (APP) and s3-cleavage of notch. |
| wb | | Sigma anti-APP C-terminal antibody against the residues 676–695 of APP695 was used in western blot to study intermolecular interactions and function of presenilin complexes. |
| wb | | Sigma rabbit polyclonal anti-APP antibody (alphaAPP/C) was used in western blot to study the interaction of AICD with FE65 and 14-3-3 modulate FE65-dependent gene transactivation. |
MILLIPORE search Millipore APP products
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| ic, ih | | CHEMICON International mouse anti–Alzheimer precursor protein A4 antibody was used in immunohistochemistry and immunocytochemistry to study the coordinated transport of phosphorylated amyloid-beta precursor protein and c-Jun NH2-terminal kinase-interacting protein-1. |
| ic, wb | | Chemicon International rabbit anti-APP antibody was used in western blot and immunocytochemistry to detect APP in CAD cells with APP transfection. |
| ic | | CHEMICON International anti-APP antibody 22C11 was used in immunocytochemistry to study the effect of APP-BP1 on APP-induced apoptosis and DNA synthesis in Alzheimer's disease brain. |
| ic | | Upstate Biotechnology anti-APP antibody 22C11 was used in immunocytochemistry to study the effect of APP-BP1 on APP-induced apoptosis and DNA synthesis in Alzheimer's disease brain. |
| ip, wb | | Chemicon International monoclonal APP NTF (22C11) antibody and polyclonal APP CTF antibody was used in Western blot and immunoprecipitation to study the biological function of presenilin-1 maturation. |
| ip, wb | | Chemicon 22C11 APP monoclonal antibody was used in western blot and immunoprecipitation to investigate the binding of the BRI2 to APP precursor protein. |
| wb | | Chemicon anti-APP monoclonal antibody was used in western blot to study Cu/Zn-superoxide dismutase (SOD1) mutant-induced motoneuronal cell death. |
| wb | | Chemicon anti-APP (Alz-90) antibody was used in Western blot to study the function of presenilin 1 mutations in kinesin-based axonal transport. |
| wb | | Chemicon anti-Amyloid beta Protein Precursor antibody was used in western blot to detect AbetaPP in HEK 293 cells transfected with various combinations of JIP-1, JNK, and MLK3. |
| wb | | Chemicon monoclonal anti-APP antibody was used in western blot to detect APP in CHO-APP695 Cells. |
| wb | | Chemicon International anti-sAPP beta antibody (APP-WT) and anti-total sAPP antibody (22C11) were used in human cells and in western blot to study the role for ubiquilin 1 in modulating amyloid precursor protein trafficking and Abeta secretion. |
| wb | | Chemicon anti-APP N-terminal antibody against the residues 99–126 of APP695 was used in western blot to study intermolecular interactions and function of presenilin complexes. |
| wb | | Chemicon rabbit polyclonal APP antibody was used in western blot to study the linking of amyloid protein precursor to the kinesin light chain through the scaffold protein JNK-interacting protein 1. |
INVITROGEN search Invitrogen APP products
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| elisa | | BioSource International human Abeta 40 colorimetric ELISA kit was used to study amyloid precursor protein cleavage through a JNK-dependent MAPK pathway. |
| ic | | Zymed anti-APP antibody was used in immunocytochemistry to detect APP in CAD cells to further characterize the nature of the speckle-associated pAPP antigen. |
| ip, wb | | CBIOSOURCE p2-1 APP monoclonal antibody was used in western blot and immunoprecipitation to investigate the binding of BRI2 to APP precursor protein. |
| ip, wb | | Zymed APP ZMD.316 polyclonal antibody was used in western blot and immunoprecipitation to investigate the binding of BRI2 to APP precursor protein. |
| ip | | BioSource International mouse anti–APP monoclonal antibody was used in immunoprecipitation to study the coordinated transport of phosphorylated amyloid-beta precursor protein and c-Jun NH2-terminal kinase-interacting protein-1. |
| ip | | BIOSOURCE anti-Amyloid beta Protein Precursor antibody was used in immunoprecipitation to detect AbetaPP in HEK 293 cells transfected with various combinations of JIP-1, JNK, and MLK3. |
| wb | | Zymed Laboratories Inc anti-APP CT695 antibody was used in western blot to study the pathway for platelet-derived growth factor to induce the beta-gamma-secretase-mediated cleavage of alzheimer's amyloid precursor protein. |
| wb | | Zymed Laboratories anti-Amyloid beta Protein Precursor antibody was used in western blot to detect AbetaPP in HEK 293 cells transfected with various combinations of JIP-1, JNK, and MLK3. |
COVANCE search Covance APP products
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| ic, ih | | Signet Laboratories mouse anti–amyloid-beta protein antibody was used in immunohistochemistry and immunocytochemistry to study the coordinated transport of phosphorylated amyloid-beta precursor protein and c-Jun NH2-terminal kinase-interacting protein-1. |
| ic | | Signet Laboratories mouse anti-human Abeta antibody was used in immunocytochemistry to detect Abeta in CAD cells to further characterize the nature of the speckle-associated pAPP antigen. |
| ip, wb | | Signet APP monoclonal antibody 6E10 was used in western blot and immunoprecipitation to investigate the binding of the BRI2 to APP precursor protein. |
| wb | | Signet 6E10 monoclonal antibody specific for beta-amyloid peptide 1-17 was used in western blot to study the characterization of an amyloid precursor protein-binding protein Fe65L2 and its novel isoforms produced by alternative splicing of the RNA. |
| wb | | Signet Laboratories monoclonal antibody 6E10 to Abeta was used in western blot to study the effect of pathogenic Abeta deposition on the expression of urokinase-type plasminogen activator (uPA) and its receptor (uPAR) in human cerebrovascular smooth muscle cells. |
| wb | | Signet Laboratories C99 antibody 6E10 was used in Western blot to study the biological function of Gamma-secretase. |
| wb | | Signet Laboratories anti-sAPP alpha antibody (6E10) was used in human cells and in western blot to study the role for ubiquilin 1 in modulating amyloid precursor protein trafficking and Abeta secretion. |
| wb | | Signet anti-APP C-terminal antibody 6E10 was used in western blot to study intermolecular interactions and function of presenilin complexes. |
| wb | | Signet Laboratories 6E10 antibody that recognizes the 1-17 of Abeta was used in western blot to study distinct gamma-secretase complexes composed of the known subunits in human cells. |
| wb | | Signet APP monoclonal antibody 6E10 was used in western blot to study the reduced secretion of APP and Abeta through the inhibition of glycosphingolipid biosynthesis. |
BECKMAN COULTER search Beckman Coulter APP products
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| ih | | Dako monoclonal anti-Abeta antibody was used in immunohistochemistry to study the selective overexpression of cannabinoid CB2 receptors and fatty acid amide hydrolase in neuritic plaque-associated glia in alzheimer's disease brains. |
ROCHE APPLIED SCIENCE search Roche Applied Science APP products
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| wb | | Roche monoclonal antibody 22C11 which recognizes amino acid residues 66–81 of APP695 was used in western blot to study a novel mechanism for the regulation of amyloid precursor protein metabolism. |
ELAN PHARMACEUTICALS
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| ic | | Elan Pharmaceuticals monoclonal antibody against Abeta- (1–5) was used in immunocytochemistry to study hypoxic augmentation of Ca2+ channel currents. |
EVOTEC
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| elisa, ih | | Evotec mouse monoclonal Abeta antibody 6H1 (against amino acids 1-17) was used in immunohistochemistry and ELISA to study Abeta 42-induced neprilysin increase. |
SENETEK
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| ih | | Senetik anti-amyloid beta antibody 6E10 was used in frozen brain sections from mice and in immunohistochemistry to study the characterization of transgenic mouse lines co-expressing mutant human presenilin 1 and amyloid precursor proteins. |
| ip | | Senetek monoclonal amyloid beta antibody 4G8 was used in immunoprecipitation to study the biological function of presenilin-1 maturation. |
| wb | | Senetek monoclonal 6E10 antibody that recognizes residues 1–17 of the Abeta domain of soluble APP alpha was used in western blot to study the effect of P2Y2 nucleotide receptors on alpha-secretase-dependent amyloid precursor protein processing. |
| wb | | Senetek monoclonal antibody 6E10 which recognizes amino acid residues 1–17 of human A beta was used in western blot to study a novel mechanism for the regulation of amyloid precursor protein metabolism. |
| wb | | Senetek anti-A beta 1-17 monoclonal antibody was used in western blot to study the enhancement of presenilin-mediated generation of amyloid beta-protein by the endoplasmic reticulum stress-inducible protein, Herp. |
SIGNET LABS
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| ih | | Signet Labs A beta peptide (6E10, 1 : 400) antibody was used in immunohistochemistry to study a novel progranulin mutation associated with variable clinical presentation and tau, TDP43 and alpha-synuclein pathology. |
Articles Reviewed |
| 1. Xiaorei Sai et al. Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid beta-protein. 2002 |
| 2. Kelly T Dineley et al. Accelerated plaque accumulation, associative learning deficits, and up-regulation of alpha 7 nicotinic receptor protein in transgenic mice co-expressing mutant human presenilin 1 and amyloid precursor proteins. 2002 |
| 3. Qi Chen et al. A novel mechanism for the regulation of amyloid precursor protein metabolism. 2002 |
| 4. M Hasan Mohajeri et al. Abeta 42-induced increase in neprilysin is associated with prevention of amyloid plaque formation in vivo. 2002 |
| 5. Fusheng Chen et al. Presenilin 1 mutations activate gamma 42-secretase but reciprocally inhibit epsilon-secretase cleavage of amyloid precursor protein (APP) and S3-cleavage of notch. 2002 |
| 6. Hiroshi Tanahashi et al. Characterization of an amyloid precursor protein-binding protein Fe65L2 and its novel isoforms lacking phosphotyrosine-interaction domains. 2002 |
| 7. Davide Gianni et al. Platelet-derived growth factor induces the beta-gamma-secretase-mediated cleavage of Alzheimer's amyloid precursor protein through a Src-Rac-dependent pathway. 2003 |
| 8. Judianne Davis et al. Amyloid beta-protein stimulates the expression of urokinase-type plasminogen activator (uPA) and its receptor (uPAR) in human cerebrovascular smooth muscle cells. 2003 |
| 9. Gustavo Pigino et al. Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport. 2003 |
| 10. Shuji Matsuda et al. Amyloid beta protein precursor (AbetaPP), but not AbetaPP-like protein 2, is bridged to the kinesin light chain by the scaffold protein JNK-interacting protein 1. 2003 |
| 11. Meir H Scheinfeld et al. Amyloid beta protein precursor is phosphorylated by JNK-1 independent of, yet facilitated by, JNK-interacting protein (JIP)-1. 2003 |
| 12. Yuzhi Chen et al. APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain. 2003 |
| 13. Cristina Benito et al. Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer's disease brains. 2003 |
| 14. Zoia Muresan et al. A phosphorylated, carboxy-terminal fragment of beta-amyloid precursor protein localizes to the splicing factor compartment. 2004 |
| 15. Keiro Shirotani et al. Identification of distinct gamma-secretase complexes with different APH-1 variants. 2004 |
| 16. Hiroshi Hasegawa et al. Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes. 2004 |
| 17. Yung-Feng Liao et al. Tumor necrosis factor-alpha, interleukin-1beta, and interferon-gamma stimulate gamma-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway. 2004 |
| 18. Jay H Chyung et al. Gamma-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage. 2005 |
| 19. Kohsuke Kanekura et al. A Rac1/phosphatidylinositol 3-kinase/Akt3 anti-apoptotic pathway, triggered by AlsinLF, the product of the ALS2 gene, antagonizes Cu/Zn-superoxide dismutase (SOD1) mutant-induced motoneuronal cell death. 2005 |
| 20. Yoshifumi Nakaya et al. Random mutagenesis of presenilin-1 identifies novel mutants exclusively generating long amyloid beta-peptides. 2005 |
| 21. Jean M Camden et al. P2Y2 nucleotide receptors enhance alpha-secretase-dependent amyloid precursor protein processing. 2005 |
| 22. Stephen T Brown et al. Hypoxic augmentation of Ca2+ channel currents requires a functional electron transport chain. 2005 |
| 23. Shuxia Zhou et al. CD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide production. 2005 |
| 24. Irfan Y Tamboli et al. Inhibition of glycosphingolipid biosynthesis reduces secretion of the beta-amyloid precursor protein and amyloid beta-peptide. 2005 |
| 25. Shuji Matsuda et al. The familial dementia BRI2 gene binds the Alzheimer gene amyloid-beta precursor protein and inhibits amyloid-beta production. 2005 |
| 26. Akio Sumioka et al. Role of 14-3-3gamma in FE65-dependent gene transactivation mediated by the amyloid beta-protein precursor cytoplasmic fragment. 2005 |
| 27. Zoia Muresan et al. Coordinated transport of phosphorylated amyloid-beta precursor protein and c-Jun NH2-terminal kinase-interacting protein-1. 2005 |
| 28. Dietrich E Lorke et al. Serotonin 5-HT2A and 5-HT6 receptors in the prefrontal cortex of Alzheimer and normal aging patients. 2006 |
| 29. Anja Persson et al. A human protein atlas based on antibody proteomics. 2006 |
| 30. Mikko Hiltunen et al. Ubiquilin 1 modulates amyloid precursor protein trafficking and Abeta secretion. 2006 |
| 31. J B Leverenz et al. A novel progranulin mutation associated with variable clinical presentation and tau, TDP43 and alpha-synuclein pathology. 2007 |