| request information: |
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| name: | alpha-Synuclein human |
| cat_no: | S7820 |
| gene id: | human SNCA(6622) |
| brand: | SIGMA |
| prod_type: | Chemical |
| name_suffix: | recombinant, expressed in Escherichia coli, N-terminal histidine tagged, >=90% (SDS-PAGE), lyophilized powder |
| storage temp.: | -20C |
| storage: | -20C |
| form: | lyophilized powder |
| shipped in: | dry ice |
| unspsc_code: | 12352202 |
| wgk: | 3 |
| mdl_no: | MFCD06411761 |
| biochem/physiol actions: | 140-amino acid protein (apparent molecular weight 19-20 kDa) encoded by a simple gene consisting of six exons on human chromosome 4. Induces polymerization of tubulin into microtubules and functions in the modulation of dopamine transporter function, regulating the synaptic tone of dopamine. Disruption of this function can ultimately lead to neurodegeneration of nerve terminals. Highly abundant in presynaptic terminals, a major component of Lewy bodies, the neuronal cytoplasmic inclusions that are a hallmark of diverse neurodegenerative disorders such as Parkinson's disease (PD), dementia with Lewy bodies (filamentous inclusions), Lewy body variant of Alzheimer's disease, and multiple system atrophy. Pathogenic point mutations in the alpha-synuclein gene are linked to familial Parkinson's disease. |
| purity: | >=90% (SDS-PAGE) |
| assay: | >=90% (SDS-PAGE) |
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more information: | company product webpage |
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