| cat_no: | | S4316 |
| name: | | Amyloid Precursor Protein beta, Secreted human |
| gene id: | | human APP(351) |
| link: | | www.sigmaaldrich.com/catalog/search ... |
| assay: | | >85% (SDS-PAGE) |
| biochem/physiol actions: | | The secreted amyloid precursor beta (sAPPbeta) is a proteolytic cleavage product of beta amyloid precursor protein (APP). APP is cleaved by beta-secretase into two fragments, sAPPbeta and beta-amyloid peptide (Abeta). The Abeta is a component of amyloid plaques, one of the major hallmarks of Alzheimer`s disease (AD), while the sAPPbeta is thought to modulate neuronal function and cell survival.; The secreted amyloid precursor beta (sAPPbeta) is a proteolytic cleavage product of beta amyloid precursor protein (APP). APP is cleaved by beta-secretase into two fragments, sAPPbeta and beta-amyloid peptide (Abeta). The Abeta is a component of amyloid plaques, one of the major hallmarks of Alzheimer`s disease (AD), while the sAPPbeta is thought to modulate neuronal function and cell survival. Mutation in APP found in Swedish familial AD pedigree increases the susceptibility of APP to beta-secretase cleavage and the formation of Abeta and sAPPbeta. In contrast, activation of protein kinase C (PKC) decreases the levels of sAPPbeta. The trans-Golgi network (TGN) is the major site for beta-secretase activity. |
| brand: | | SIGMA |
| form: | | solution |
| mdl_no: | | MFCD06201921 |
| mol wt: | | mol wt ~100 kDa by SDS-PAGE |
| name_suffix: | | >85% (SDS-PAGE), recombinant, expressed in Escherichia coli (N-terminal histidine-tagged), solution, sterile; 0.2 mum filtered |
| physical form: | | 0.2 mum filtered solution in 20 mM Tris (pH 7.4), 0.5 M NaCl, 1 mM EDTA, 5 mM betaME, 2 mug/ml aprotinin |
| prod_type: | | Chemical |
| purity: | | >85% (SDS-PAGE) |
| recombinant: | | expressed in Escherichia coli (N-terminal histidine-tagged) |
| shipped in: | | dry ice |
| storage: | | -70C |
| storage temp: | | -70C |
| syns: | | Amyloid Precursor Protein beta, Secreted; sAPPβ |
| unspsc_code: | | 12352209 |
| wgk: | | - |
| more information: | | company product webpage |
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