| cat_no: | | PI0100 |
| name: | | phospho-Insulin Receptor beta Subunit (pTyr1158) ELISA |
| gene id: | | human INSR(3643) |
| link: | | www.sigmaaldrich.com/catalog/search ... |
| analysis note: | | The sensitivity is <0.8 units/mL, which is 2x more sensitive than immunoblotting. Peptide competition shows that only the phosphopeptide corresponding to the region surrounding tyrosine 1158 blocks the ELISA signal. |
| application: | | phospho-Insulin Receptor beta Subunit (pTyr1158) ELISA is specific for native and recombinant IR that is phosphorylated at tyrosine 1158.; The assay is designed for the quantitative determination of human, mouse, and rat IR in cell lysates. |
| biochem/physiol actions: | | Insulin receptor (IR) belongs to the superfamily of the growth factor receptor tyrosine kinases that regulate multiple signaling pathways through activation of a series of phosphorylation cascades. Once activated, the IR initiates a variety of metabolic functions including glucose transport, glycogen synthesis, protein synthesis, translational control, and mitogenesis. |
| brand: | | SIGMA |
| name_suffix: | | beta Subunit (pTyr1158) phospho, sufficient for 96 tests |
| prod_type: | | Chemical |
| r_codes: | | 23-34 |
| ridadr: | | UN 3316 9/PG 3 |
| s_codes: | | 26-36/37/39-45 |
| shipped in: | | wet ice |
| storage: | | 2-8C |
| storage temp: | | 2-8C |
| syns: | | Insulin Receptor beta Subunit ELISA; IR beta Subunit ELISA |
| unspsc_code: | | 12352203 |
| more information: | | company product webpage |