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| name: | Protein Kinase C isozyme panel human |
| cat_no: | P6862 |
| gene id: | human PRKD1(5587); human PRKCE(5581); human PRKCA(5578); human PRKCG(5582); human PRKCH(5583); human PRKCD(5580); human PRKCQ(5588); human PRKCB1(5579); human PRKCI(5584) |
| brand: | SIGMA |
| prod_type: | Chemical |
| name_suffix: | 95% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, buffered aqueous solution |
| storage temp.: | -70C |
| storage: | -70C |
| form: | buffered aqueous solution |
| shipped in: | dry ice |
| syns: | PKC control panel human |
| unspsc_code: | 12352204 |
| biochem/physiol actions: | Protein Kinase C (PKC) is a serine/threonine kinase that is activated intracellularly by signal transduction pathways that produce DAG from phosphatidylinositol diphosphate (PIP2) and phosphatidylcholine (PC) through the action of various activated phospholipases. Phorbol esters also stimulate PKC. At least 11 PKC isozymes have been identified that differ in primary structure, tissue distribution, subcellular localization, response to extracellular signals, and substrate specificity. The isozymes can be grouped into three subfamilies. Members of the first family require Ca2+ and phospholipid and include PKCalpha, betaI, betaII, and gamma. Members of the second family are phospholipid-dependent but Ca2+-independent, and include PKCdelta, epsilon, eta, and theta. Members of the third family are not activated by either DAG or phorbol esters and include PKCξ, mu, and iota. |
| purity: | 95% (SDS-PAGE) |
| assay: | 95% (SDS-PAGE) |
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more information: | company product webpage |
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