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| name: | Protein C from human plasma |
| cat_no: | P2200 |
| gene id: | human PROC(5624) |
| brand: | SIGMA |
| prod_type: | Chemical |
| name_suffix: | Activated, lyophilized powder, >=90% (SDS-PAGE) |
| storage temp.: | -20C |
| storage: | -20C |
| form: | lyophilized powder |
| physical form: | Lyophilized powder from 20 mM Tris-HCl, pH 7.4, containing 0.1 M NaCl |
| syns: | Activated Protein C |
| unspsc_code: | 12352202 |
| wgk: | 3 |
| mdl_no: | MFCD00165567 |
| mol wt: | heavy chain mol wt 41 kDa; light chain mol wt 21 kDa |
| biochem/physiol actions: | Protein C is a plasma, vitamin K-dependent zymogen of a serine protease that can inhibit blood coagulation by inhibiting thrombin formation, selectively inactivating Factors Va and VIIIa. The Protein C anticoagulant pathway is triggered when thrombin binds to the endothelial cell proteoglycan, thrombomodulin. This complex, which cannot clot blood, is a potent activator of the protein C zymogen. Activation involves the release of a dodecapeptide from the N-terminal domain of the heavy chain. The activated Protein C (APC) then binds to protein S on cell surfaces and inactivates the coagulation factors Va and VIIIa by proteolysis. APC has also been shown to bind to receptors on the endothelium of large blood vessels. |
| s_codes: | 36/37 |
| purity: | >=90% (SDS-PAGE) |
| assay: | >=90% (SDS-PAGE) |
| iod_codes: | B |
| solubility: | H2O: 1 mg/mL |
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more information: | company product webpage |
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