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| name: | Oncostatin M human |
| cat_no: | O9635 |
| gene id: | human OSM(5008) |
| brand: | SIGMA |
| prod_type: | Chemical |
| name_suffix: | >97% (SDS-PAGE), recombinant, expressed in Escherichia coli, lyophilized powder, cell culture tested |
| storage temp.: | -20C |
| storage: | -20C |
| form: | lyophilized powder |
| physical form: | Lyophilized from a 0.2 mum filtered solution in 30% acetonitrile and 0.1% trifluoroacetic acid containing 50 mug bovine serum albumin per 1 mug of cytokine. |
| syns: | OSM |
| unspsc_code: | 12352207 |
| wgk: | 3 |
| mdl_no: | MFCD00166731 |
| biochem/physiol actions: | Oncostatin M, LIF, G-CSF, IL-6, and ciliary neurotrophic factor (CNTF) are structurally related members of the same cytokine family sharing similarities in their primary amino acid sequences, predicted secondary structure, and receptor components. Oncostatin M is a growth-regulating cytokine, affecting a number of tumor and normal cells. This material was first identified by its ability to inhibit the growth of A375 melanoma cells and other human tumor cells, but not inhibit the growth of normal human fibroblasts. It acts synergistically with TGF beta1 to inhibit the proliferation of tumor cells like A375 melanoma cells. It induces an increase in LDL receptor expression and LDL uptake by hepatoma cells. OSM activates synovial fibroblast-like cells to produce urokinase type plasminogen activator. Oncostatin M is secreted by macrophages and activated T lymphocytes. |
| purity: | >97% (SDS-PAGE) |
| assay: | >97% (SDS-PAGE) |
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more information: | company product webpage |
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