| cat_no: | | O2135 |
| name: | | Ogg1 from mouse |
| gene id: | | mouse Ogg1(18294) |
| link: | | www.sigmaaldrich.com/catalog/search ... |
| assay: | | >=90% (SDS-PAGE) |
| biochem/physiol actions: | | Ogg1 (8-oxoguanine-DNA glyosylase) is a DNA repair protein that is primarily responsible for repair of 8-oxo-guanine (8-oxo-G). It possesses both DNA glycosylase and AP lyase activity and is a functional analog of the bacteria Fpg. Ogg1 releases 8-oxo-G from mutated DNA and nicks the DNA strand. Although its glycosidase activity is very efficient, its lyase activity is weak and is highest for substrates having a cytosine (C) as the opposite base. Ogg1 is a beta-lyase generating a alpha,beta-unsaturated sugar moiety at the 3'-terminus. Murine Ogg1 displays 84% identity to the human alpha-Ogg1. Its activity is determined on double-stranded oligonucleotide containing 8-oxo-guanine having a C opposite the lesion. |
| brand: | | SIGMA |
| form: | | buffered aqueous glycerol solution |
| iod_codes: | | Xi |
| mdl_no: | | MFCD02264758 |
| mol wt: | | mol wt 38.8 kDa (345 amino acid protein) |
| name_suffix: | | >=90% (SDS-PAGE), recombinant, expressed in Escherichia coli, buffered aqueous glycerol solution, >20,000 units/mg protein |
| physical form: | | Solution in 50% (w/v) glycerol containing 20 mM Tris, pH 7.5, 200 mM sodium chloride, 1 mM EDTA, and 1 mM DTT. |
| prod_type: | | Chemical |
| purity: | | >=90% (SDS-PAGE) |
| r_codes: | | 36/37/38 |
| recombinant: | | expressed in Escherichia coli |
| s_codes: | | 26-36 |
| shipped in: | | wet ice |
| storage: | | -20C |
| storage temp: | | -20C |
| syns: | | 8-Oxoguanine-DNA glycosylase from mouse |
| unspsc_code: | | 12352204 |
| wgk: | | 1 |
| more information: | | company product webpage |