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| name: | Monoclonal Anti-Nicotinic Acetylcholine Receptor (alpha1, alpha3, alpha5 Subunits) antibody produced in rat |
| cat_no: | M217 |
| gene id: | human CHRNA3(1136); human CHRNA5(1138); human CHRNA1(1134) |
| brand: | SIGMA |
| prod_type: | Chemical |
| name_suffix: | clone mAb 35, purified immunoglobulin, buffered aqueous solution |
| storage temp.: | -20C |
| storage: | -20C |
| form: | buffered aqueous solution |
| physical form: | Solution in 20 mM Na3PO4, pH 7.2, containing 150 mM NaCl and 0.05 % sodium azide. |
| antibody form: | purified immunoglobulin |
| shipped in: | dry ice |
| species reactivity: | chicken, human, eel |
| application(s): | immunohistochemistry (frozen sections): 1:3,000 |
| immunogen: | nicotinic acetylcholine receptor from the electric eel Electrophorus. |
| unspsc_code: | 12352203 |
| wgk: | 2 |
| mdl_no: | MFCD00677279 |
| clone: | mAb 35 |
| isotype: | IgG1 |
| legal information: | Sold with permission of the Salk Institute |
| specificity: | Binds to the main immunogenic region on the extracellular surface of the alpha1 subunit of muscle AChR's and to homologous regions on alpha3 and alpha5 subunits of neuronal AChR's. The epitope is located on the extracellular surface of the alpha1 subunit of the muscle nicotinic acetylcholine receptor. The antibody binds to denatured chick alpha5 AChR, but does not bind well to denatured alpha3, alpha4, alpha7, alpha8, and beta2. It may also bind beta3 due to homology of main immunogenic region. May be used to localize and detect the alpha1, alpha3 and alpha5 subunits of the nicotinic acetylcholine receptor (AChR). |
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more information: | company product webpage |