| cat_no: | | I3769 |
| name: | | Insulin-like Growth Factor-I human |
| gene id: | | human IGF1(3479) |
| link: | | www.sigmaaldrich.com/catalog/search ... |
| analysis note: | | The biological activity is measured by a dose-dependent cell proliferation assay. ED50 corresponds to a specific activity of at least 5 x 105 units/mg. |
| assay: | | >=97% (SDS-PAGE or HPLC) |
| biochem/physiol actions: | | IGF-I also known as somatomedin C, is secreted from the liver into circulation in a process regulated by pituitary growth hormone (GH) and so it mediates the growth-promoting activity of GH. In the developing embryo IGF-I is expressed primarily by mesenchymal-derived cells. After birth IGF-I expression in most extrahepatic tissues declines and hepatic expression of IGF-I becomes GH-regulated. Expression of IGF-I outside the liver is regulated differently, depending on the specific tissues. For example, gonadotropins and sex steroids regulate IGF-I expression within the reproductive system, while parathyroid hormone and sex steroids regulate IGF-I expression in bone. IGF-I is produced in several human tumors. IGF-I is mitogenic for a variety of cells including fibroblasts, osteoblasts, smooth muscle cells, fetal brain cells, neuroglial cells, and erythroid progenitor cells. IGF-I exerts its actions exclusively through the IGF-I receptor (IGF-IR). IGF-I induces endothelial cell migration and is involved in the regulation of angiogenesis. |
| brand: | | SIGMA |
| form: | | lyophilized powder |
| mdl_no: | | MFCD00081716 |
| name_suffix: | | recombinant, expressed in Escherichia coli, lyophilized powder, cell culture tested |
| physical form: | | Lyophilized from a 0.2 mum filtered solution, water as solvent, no additives |
| prod_type: | | Chemical |
| purity: | | >=97% (SDS-PAGE or HPLC) |
| recombinant: | | expressed in Escherichia coli |
| storage: | | -20C |
| storage temp: | | -20C |
| syns: | | IGF; IGF-I; somatomedin c |
| total impurities: | | Endotoxin, tested |
| unspsc_code: | | 12352207 |
| wgk: | | 3 |
| more information: | | company product webpage |
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