| cat_no: | | I3268 |
| name: | | Interleukin-6 human |
| gene id: | | human IL6(3569) |
| link: | | www.sigmaaldrich.com/catalog/search ... |
| assay: | | >=90% (SDS-PAGE) |
| biochem/physiol actions: | | Interleukin-6 is a multifunctional protein originally discovered in the media of cells stimulated with double stranded RNA. IL-6 appears to be directly involved in the responses that occur after infection and injury and may prove to be as important as IL-1 and TNF-alpha in regulating the acute phase response. IL-6 is reported to be produced by fibroblasts, activated T cells, activated monocytes or macrophages, and endothelial cells. It acts upon a variety of cells, including fibroblasts, myeloid progenitor cells, T cells, B cells and hepatocytes. IL-6 induces multiple effects, as indicated by its numerous synonyms: plasmacytoma growth factor (PCT-GF), interferon-beta-2 (IFN-beta2), monocyte derived human B cell growth factor, B cell stimulating factor (BSF-2), hepatocyte stimulating factor (HSF), Interleukin Hybridoma/Plasmacytoma-1 (IL-HP1). In addition, IL-6 appears to interact with IL-2 in the proliferation of T lymphocytes. IL-6 also potentiates the proliferative effect of IL-3 on multipotential hematopoietic progenitors. |
| brand: | | SIGMA |
| form: | | buffered aqueous solution |
| iod_codes: | | B |
| mdl_no: | | MFCD00131403 |
| mol wt: | | major glycoprotein mol wt 26 kDa; minor glycoprotein mol wt 29 kDa |
| name_suffix: | | from human (osteosarcoma cells), cell culture tested |
| physical form: | | Solution in 0.2 mum filtered phosphate buffered saline containing 0.1% human serum albumin. |
| prod_type: | | Chemical |
| purity: | | >=90% (SDS-PAGE) |
| shipped in: | | dry ice |
| storage: | | -20C |
| storage temp: | | -20C |
| syns: | | IL-6 |
| total impurities: | | Endotoxin, tested |
| unspsc_code: | | 12352207 |
| wgk: | | 3 |
| more information: | | company product webpage |
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