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| name: | Interleukin-12 human |
| cat_no: | I2276 |
| gene id: | human IL12B(3593); human IL12A(3592) |
| brand: | SIGMA |
| prod_type: | Chemical |
| name_suffix: | >=97% (SDS-PAGE and N-terminal analysis), recombinant, expressed in Sf21 cells, lyophilized powder, cell culture tested |
| storage temp.: | -20C |
| storage: | -20C |
| form: | lyophilized powder |
| physical form: | Lyophilized from a 0.2 mum filtered solution in phosphate buffered saline containing 0.25 mg bovine serum albumin. |
| syns: | IL-12 |
| unspsc_code: | 12352207 |
| wgk: | 3 |
| mdl_no: | MFCD00212975 |
| mol wt: | glycoprotein mol wt 75 kDa |
| biochem/physiol actions: | Interleukin-12 (IL-12) was identified as a factor secreted by human Epstein-Barr (EBV)-transformed B cell lines. IL-12, or Natural Killer Cell Stimulatory Factor (NKSF), is a 75 kDa disulfide-linked heterodimer of a 35 kDa subunit and 40 kDa subunit. IL-12 is produced predominantly by monocytes and NK cells and induces T cells and NK cells to produce IFN-gamma. Human IL-12 is not active on mouse cells, but murine IL-12 is active on both murine and human lymphocytes. The biological activity of recombinant human IL-12 was measured by its ability to stimulate the proliferation of PHA-activated human T lymphoblasts. IL-12 has anti-angiogenic properties. |
| purity: | >=97% (SDS-PAGE and N-terminal analysis) |
| assay: | >=97% (SDS-PAGE and N-terminal analysis) |
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more information: | company product webpage |