| cat_no: | | G1777 |
| name: | | Glial Cell Line-derived Neurotrophic Factor human |
| gene id: | | human GDNF(2668) |
| link: | | www.sigmaaldrich.com/catalog/search ... |
| analysis note: | | The biological activity of GDNF is determined by the dose-dependent dopamine uptake by rat ventral mesencephalic cultures. |
| assay: | | >98% (SDS-PAGE and HPLC) |
| biochem/physiol actions: | | Glial Cell Line-Derived Neurotrophic Factor is a member of the cysteine-knot superfamily of growth factors that assume stable dimeric protein structures. GDNF is founding member of the GDNF family of ligands, which to date include GDNF, neurturin (NTN), persephin (PSP) and artemin (ART). GDNF is a glycosylated disulfide-linked homodimeric protein of ~15 kDa. Mature rat and human GDNF share ~93% sequence homology, with strong species cross-reactivity. GDNF signals through a multicomponent receptor system, composed of a RET and one of the four GFRalpha (alpha1-alpha4) receptors. GDNF specifically promotes dopamine uptake and survival and morphological differentiation of midbrain neurons. Using the Parkinson's disease mouse model, GDNF has been shown to improve conditions such as bradykinesia, rigidity, and postural instability. GDNF promotes survival of various neuronal cells in central and peripheral nervous systems and different stages of development, including motoneurons, midbrain dopaminergic neurons, Purkinje cells and sympathetic neurons. Cells known to express GDNF include Sertoli cells, type 1 astrocytes, Schwann cells, neurons, pinealocytes and skeletal muscle cells. In addition, exogenously applied GDNF has been shown to rescue damaged facial motor neurons in vivo. |
| brand: | | SIGMA |
| form: | | lyophilized powder |
| mdl_no: | | MFCD00285867 |
| name_suffix: | | >98% (SDS-PAGE and HPLC), recombinant, expressed in Escherichia coli, lyophilized powder, cell culture tested |
| physical form: | | Lyophilized from a 0.2 mum filtered solution of 10 mM sodium citrate and 150 mM sodium chloride containing 0.5 mg bovine serum albumin. |
| prod_type: | | Chemical |
| purity: | | >98% (SDS-PAGE and HPLC) |
| recombinant: | | expressed in Escherichia coli |
| storage: | | -20C |
| storage temp: | | -20C |
| syns: | | GDNF |
| total impurities: | | Endotoxin, tested |
| unspsc_code: | | 12352207 |
| wgk: | | 3 |
| more information: | | company product webpage |
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