| name: | Monoclonal Anti-CD74 antibody produced in mouse |
| cat_no: | C2955 |
| gene id: | human CD74(972) |
| brand: | SIGMA |
| link: | www.sigmaaldrich.com/catalog/search ... |
| prod_type: | Chemical |
| name_suffix: | clone LN-2, ascites fluid, Immunohistology Grade |
| storage temp.: | -20C |
| storage: | -20C |
| unspsc_code: | 12352203 |
| shipped in: | dry ice |
| antibody form: | ascites fluid |
| application(s): | immunoprecipitation: suitable;immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:200 using human tonsil sections;flow cytometry: suitable |
| species reactivity: | human |
| immunogen: | nuclei from a SU-DHL-4 diffuse histiocytic human lymphoma cell line. |
| mdl_no: | MFCD00212292 |
| wgk: | 3 |
| specificity: | Recognizes the cell surface MHC class II-associated invariant chain molecule (IIi) expressed on B cells, some monocytes and interdigitating histiocytes. The antibody reacts with human mantle zone and germinal center B lymphocytes, interdigitating reticulum cells and small spindle shaped connective tissue macrophages in tonsils, lymph nodes and spleen and with medullary B cells and dendritic cells of the thymus. It also reacts with B cell lymphomas, Hodgkin's disease mononuclear cells, Reed-Sternberg cells and some chronic B lymphocytic leukemia cells. Tubercular granuloma giant cells and intertubular kidney cells, and focal reactivity with rare cases of lung squamous cell carcinoma, transitional cell carcinoma of the urinary bladder and a malignant melanoma cell line are also stained. The staining pattern of lymphocytes was described as perinuclear or cell membrane, while that of tissue macrophages was described as cytoplasmic. The antibody is reactive in immunoprecipitation (33, 35, 41 kDa), flow cytometry and immunohistochemistry using frozen sections or B5-solution fixed or neutral buffered-formalin fixed, paraffin-embedded sections.4th Workshop: code no. LN25th Workshop: code no. CD74.3 |
| clone: | LN-2 |
| isotype: | IgG1 |
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