| cat_no: | | B1059 |
| name: | | Bcl-w (Minus C-Terminus) human |
| gene id: | | human BCL2L2(599) |
| link: | | www.sigmaaldrich.com/catalog/search ... |
| analysis note: | | Measured by its ability to inhibit caspase-8-cleaved human BID-mediated release of cytochrome c from isolated mouse liver mitochondria using ELISA. |
| assay: | | >95% (SDS-PAGE) |
| biochem/physiol actions: | | Like Bcl-2 and Bcl-x, the Bcl-w protein promotes cell survival, in contrast to other close homologues, Bax and Bak, which facilitate cell death. Bcl-w is an anti-apoptotic member of the Bcl-2 family that prevents release of cytochrome c from the mitochondrial intermembrane space into the cytosol. It is required for normal sperm maturation. Natural Bcl-w contains a C-terminal mitochondrial targeting sequence. |
| brand: | | SIGMA |
| form: | | buffered aqueous glycerol solution |
| mdl_no: | | MFCD03846039 |
| mol wt: | | mol wt 18 kDa by SDS-PAGE |
| name_suffix: | | >95% (SDS-PAGE), recombinant, expressed in Escherichia coli, buffered aqueous glycerol solution |
| physical form: | | Supplied as a 0.2 mum filtered solution in 25 mM HEPES, pH 7.5, 0.1 M KCl, and 10% glycerol. |
| prod_type: | | Chemical |
| purity: | | >95% (SDS-PAGE) |
| recombinant: | | expressed in Escherichia coli |
| shipped in: | | wet ice |
| storage: | | -20C |
| storage temp: | | -20C |
| unspsc_code: | | 12352202 |
| wgk: | | 3 |
| more information: | | company product webpage |