| Catalog Number: | NB 100-698 |
| Product Name: | VEGF antibody |
| Short Description: | Rabbit polyclonal to VEGF |
| Clone Number: | request info |
| Clonality: | Polyclonal |
| Concentration: | 0.2 |
| Notes: | request info |
| Immunogen Description: | Synthetic peptide to the N-terminus of human VEGF. This antibody reacts with 165, 189 and 121 amino acid splice variants of VEGF of human, to a lesser extent, mouse and rat |
| Epitope: | request info |
| Specificity: | request info |
| Cross Reactivity: | Cross-reacts with Human and to a lesser extent Rat and Mouse. Not yet tested in other species. |
| Form: | 0.5 ml of protein A purified sera. |
| Uses: | Immunohistochemistry (formalin fixed paraffin embedded): 25-50 ug/ml for 30 min at RT (ABC method).* Not tested in other applications. *Optimal dilutions / concentrations should be determined by the end user. |
| Cellular Localisation: | Cytoplasmic, cell membrane, extracellular matrix |
| Positive Control: | Hemangiosarcomas. |
| Relevance: | VEGF (Vascular Endothelial Growth Factor) is a homodimeric, disulfide-linked glycoprotein involved in angiogenesis which promotes tumor progression and metastasis. It exhibits potent mitogenic and permeability inducing properties specific for the vascular endothelium. Of the four isoforms of VEGF, the smaller two, VEGF 165 and VEGF 121, are secreted proteins and act as diffusible agents, whereas the larger two (VEGF 189 and VEGF 206) remain cell associated. |
| References: | request info |
| User Storage Instructions: | Refrigerate at 4 degrees C. Do not freeze. |
| Product Type Name: | Primary Antibody |
| Purity Description: | Protein A purified |
| SubClass: | IgG |
| Raised In: | Rabbit |
| Storage Buffer Description: | 10mM PBS [pH6.0], 0.2%BSA, 0.09% sodium azide |
| List Price: | 275 |
| General References: | Int J Oncol 8:505-511 (1996). Boocock CA et al. Expression of vascular endothelial growth factor and its receptors flt and KDR in ovarian carcinoma. J Natl Cancer Inst 87:506-16 (1995). Brown LF et al. Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in breast cancer. Hum Pathol 26:86-91 (1995). |
| Novus References: | request info |
| Application Summary: | IHC-P |
| Species Summary: | Hu, Rt, Mu |
| Alternate Names: | Vascular Endothelial Growth Factor antibody, Vascular Permeability Factor antibody, VEGFA antibody, VPF antibody |
| Package Size: | 0.5 ml |