| CatalogCode: | S-010-100 |
| ProductName: | Neurturin Antibody |
| Product Description: | Sheep Polyclonal anti-Neurturin |
| Clonality: | Polyclonal |
| Immunogen: | Recombinant human Neurturin (rhNTN) |
| Specificity: | Dot blot shows no cross reactivity to GDNF. |
| CrossReactivity: | This antibody is known to react with human, mouse and rat. Not yet tested against other species. |
| Packaging: | 0.1 ml Sheep antisera. |
| Uses: | IHC, WB, immunoblot, 1-site ELISA. Recommended to be used at a dilution of 1:2000-3000 for immunohistochemistry and Western blot, 1: 2000 to 1:4000 for ELISA. The optimal working dilution should be determined by the end user. |
| Localization: | Accession Number: NRTN_HUMAN |
| Background: | Neurturin (NTN) is a member of the GDNF family of neurotrophic factors. This protein is a potent survival factor for several populations of central and peripheral neurons in mature and developing rodents. FUNCTION: Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells. SUBUNIT: Homodimer; disulfide-linked. SUBCELLULAR LOCATION: Secreted protein. DISEASE: Defects in NRTN are a cause of Hirschsprung disease (HSCR). In association with mutations of RET gene, and possibly with other loci, defects in NRTN are involved in Hirschsprung disease. This genetic disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction. SIMILARITY: Belongs to the TGF-beta family. GDNF subfamily. |
| ProductRef: | 1. Kotzbauer, et al. (1996) Nature. 384(6608):467-70 ; 2. Golden, et al. (1998), J Comp Neurol 398, 139-50 ; 3. Xian, et al. (1999), Brain Res. 835(2):247-58 |
| Host_Name: | Sheep |
| Buffer: | Reconstitute in 100 ul of sterile water. Centrifuge to remove any insoluble material. |
| ListPrice: | 275 |
| AppSummary: | IHC, WB |
| SpeciesSummary: | Hu, Mu, Rt |
| ALTnames: | anti-Neurturin. GENA NAME: NRTN antibody |
| ProteinTarget: | Neurturin |
| PackageSize: | 0.1 ml |
| NotesMain: | This product is distributed for biosensis Pty Ltd, Australia. For the most up-to-date information regarding this product, please go to biosensis' website: http://www.biosensis.com/product_info.php?products_id=67 |
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