| CatalogCode: | R-164-250 |
| ProductName: | GFAP Antibody |
| Product Description: | Rabbit Polyclonal anti-GFAP |
| Clonality: | Polyclonal |
| Immunogen: | Native GFAP extracted from rat spinal cord (scroll down to see Spcs X-react), biosensis |
| CrossReactivity: | Human, mouse, rat and cow and expected to react to GFAP protein of origins of cat, dog and sheep |
| Packaging: | 0.25 mg Rabbit antisera. |
| Background: | DISEASE: Defects in GFAP are a cause of Alexander disease. Alexander disease is a rare disorder of the central nervous system. It is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of Rosenthal fibers which are cytoplasmic inclusions in astrocytes. The most common form affects infants and young children, and is characterized by progressive failure of central myelination, usually leading to death usually within the first decade. Infants with Alexander disease develop a leukoencephalopathy with macrocephaly, seizures, and psychomotor retardation. Patients with juvenile or adult forms typically experience ataxia, bulbar signs and spasticity, and a more slowly progressive course. SIMILARITY: Belongs to the intermediate filament family. GFAP is believed to be essential in motility and form of astrocytes by stabilizing the astrocytic processes. |
| ProductRef: | 1. Reeves S.A, et al. Proc. Natl. Acad. Sci. U.S.A. 86:5178-5182(1989). ; 2. Brenner M, et al. Brain Res. Mol. Brain Res. 7:277-286(1990). ; 2. Isaacs A, et al. Genomics 51:152-154(1998). ; 3. Ota T, et al. Nat. Genet. 36:40-45(2004). ; 4. Nielsen A.L, et al. J. Biol. Chem. 277:29983-29991(2002). ; 5. Singh R, et al. Genomics 82:185-193(2003). ; 6. Brenner M, et al. Nat. Genet. 27:117-120(2001). ; 7. Brockmann K, et al. Eur. Neurol. 50:100-105(2003). ; 8. Stumpf E, et al. Arch. Neurol. 60:1307-1312(2003). ; 9. Sawaishi Y, et al. Neurology 58:1541-1543(2002). ; 10. Aoki Y, et al. Neurosci. Lett. 312:71-74(2001). |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | Reconstitute in 250 ul of sterile water. Centrifuge to remove any insoluble material. |
| ListPrice: | 275 |
| SpeciesSummary: | Bv, Hu, Mu, Rt |
| ALTnames: | anti-Astrocyte antibody, anti-Glial Fibrillary Acidic Protein antibody, anti-FLJ45472 antibody |
| ProteinTarget: | GFAP |
| PackageSize: | 0.25 mg |
| NotesMain: | This product is distributed for biosensis Pty Ltd, Australia. For the most up-to-date information regarding this product, please go to biosensis' website: http://www.biosensis.com/product_info.php?products_id=238 |
order or
more information: | company product webpage |
| request information: |
|
|