| CatalogCode: | R-121-100 |
| ProductName: | TrkB Antibody |
| Product Description: | Rabbit Polyclonal anti-TrkB |
| Clonality: | Polyclonal |
| Immunogen: | A synthetic peptide (AFPRLEPNSIDPENC) as part of rat TrkB (aa: 23-36) conjugated to KLH |
| Specificity: | Sequence was chosen to avoid cross reactivity with trkA and trkC. |
| CrossReactivity: | This antiserum recognises human and rat TrkB. Cross reactivity with other species has not yet been tested. |
| Packaging: | 0.1 ml Whole Rabbit antisera. |
| Uses: | IHC. A dilution of 1:1000 to 1:3000 is recommended for this application. The optimal working dilution should be determined by the end user. The sequence of the immunogen and the conjugate are identical to the one used by Yan et al (see the Refs) and the antiserum appears to have similar characteristics. |
| Localization: | Accession Number: NTRK2_RAT |
| Background: | FUNCTION: Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1. CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. SUBUNIT: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures (By similarity). Binds APS. Interacts with SQSTM1. SUBCELLULAR LOCATION: Membrane; single-pass type I membrane protein. ALTERNATIVE PRODUCTS: 3 named isoforms produced by alternative splicing. Additional isoforms seem to exist. TISSUE SPECIFICITY: The different forms are differentially expressed in various cell types. Isoform T2 is primarily expressed in neurons. PTM: Ligand-mediated auto-phosphorylation. SIMILARITY: Belongs to the Tyr protein kinase family. Insulin receptor subfamily. SIMILARITY: Contains 2 Ig-like C2-type (immunoglobulin-like) domains. SIMILARITY: Contains 2 LRR (leucine-rich) repeats. SIMILARITY: Contains 1 protein kinase domain. |
| ProductRef: | 1. Yan Q et al. J Comp Neurol 378:135-57 (1997). ; 2. Stoilov, P., et al., Biochem. Biophys. Res. Commun. 290(3):1054-1065 (2002). ; 3. Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002). ; 4. Nakagawara, A., et al., Genomics 25(2):538-546 (1995). ; 5. Haniu, M., et al., Arch. Biochem. Biophys. 322(1):256-264 (1995). ; 6. Allen, S.J., et al., Neuroscience 60(3):825-834 (1994). |
| Purity: | Whole antisera |
| Host_Name: | Rabbit |
| Buffer: | Reconstitute in 100 ul of sterile water. Centrifuge to remove any insoluble material. |
| ListPrice: | 285 |
| AppSummary: | IHC, IHC-P |
| SpeciesSummary: | Hu, Rt |
| ALTnames: | anti-BDNF/NT-3 growth factors receptor antibody, anti-Neurotrophic tyrosine kinase receptor type 2 antibody, anti-TrkB tyrosine kinase antibody, anti-GP145-TrkB/GP95-TrkB antibody, anti-Trk-B. GENE NAME: Ntrk2 antibody, anti-Trkb antibody |
| ProteinTarget: | TrkB |
| PackageSize: | 0.1 ml |
| NotesMain: | This product is distributed for biosensis Pty Ltd, Australia. For the most up-to-date information regarding this product, please go to biosensis' website: http://www.biosensis.com/product_info.php?products_id=198 |
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