| CatalogCode: | R-070-100 |
| ProductName: | APP Antibody |
| Product Description: | Rabbit Polyclonal anti-APP |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptides (C-ETHLHW HTVAKET, aa: 145-157; C-HAH FQKAKERLEA KHRER, aa: 388-405; C-KKKQYTS IHHGVVE, aa: 724-737) as parts of human APP isoform A conjugated to KLH |
| Specificity: | Specificity for APP was confirmed by IHC. |
| CrossReactivity: | This antiserum is known to react with rat APP. Reactivity with other species have not yet been tested. |
| Packaging: | 0.1 ml Rabbit antisera. |
| Uses: | IHC. Recommended to be used at a dilution of 1:500 to 1:3000 for immunohistochemistry. This antiserum has not yet been tested for western blot. The optimal working dilution should be determined by the end user. |
| Localization: | Accession Number: APP_HUMAN |
| Background: | FUNCTION: Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1/Tip60 and inhibit Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity. Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. May be involved in copper homeostasis/oxidative stress through copper ion reduction. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. FUNCTION: Beta-amyloid peptides are lipophilic metal chelators with metal-reducing activity. Bind transient metals such as copper, zinc and iron. Rat and mouse beta-amyloid peptides bind only weakly transient metals and have little reducing activity due to substitutions of transient metal chelating residues. Beta-APP42 may activate mononuclear phagocytes in the brain and elicit inflammatory responses. Promotes both tau aggregation and TPK II-mediated phosphorylation (By similarity). FUNCTION: The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis. SUBUNIT: Binds, via its C-terminus, to the PID domain of several cytoplasmic proteins, including APBB family members, the APBA family, MAPK8IP1, SHC1, Numb and Dab1. Binding to Dab1 inhibits its serine phosphorylation. Also interacts with GPCR-like protein BPP, FPRL1, APPBP1, IB1, KNS2 (via its TPR domains), APPBP2 (via BaSS) and DDB1. In vitro, it binds MAPT via the MT-binding domains. Associates with microtubules in the presence of ATP and in a kinesin-dependent manner. Interacts, through a C-terminal domain, with GNAO1. Amyloid beta-42 binds CHRNA7 in hippocampal neurons. Beta-amyloid associates with HADH2. TISSUE SPECIFICITY: different isoforms in different tissues: kidney. brain. liver. hippocampus, substania nigra pars compacta and cerebellum. In the cerebellum, all the isoforms are abundantly expressed in Purkinje cells. |
| ProductRef: | 1. Wilson, C.A., et al., J. Neurosci. Res. 74: 361-369 (2003). ; 2. Andreasen, N., et al., World J. Biol. Psychiatry 4: 147-155 (2003). ; 3. Guenette, S.Y. Neuromolecular Med. 4: 147-160 (2003). |
| Host_Name: | Rabbit |
| Buffer: | Reconstitute in 100 ul of sterile water. Centrifuge to remove any insoluble material. |
| ListPrice: | 285 |
| AppSummary: | IHC |
| SpeciesSummary: | Rt |
| ALTnames: | anti-AAA antibody, anti-ABETA antibody, anti-ABPP antibody, anti-AD1 antibody, anti-APPI antibody, anti-CTFgamma antibody, anti-CVAP antibody, anti-PN2 antibody |
| ProteinTarget: | APP |
| PackageSize: | 0.1 ml |
| NotesMain: | This product is distributed for biosensis Pty Ltd, Australia. For the most up-to-date information regarding this product, please go to biosensis' website: http://www.biosensis.com/product_info.php?products_id=36 |
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