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| Catalog Code: | PAB0622 |
| Product Name: | STAT6 Phosphospecific Antibody |
| Product Description: | Rabbit Polyclonal anti-STAT6 - signal transducer and activator of transcription 6, interleukin-4 induced [Tyr641] |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Gene ID: | 6778 |
| Gene Symbol: | STAT6 |
| Reference Sequence: | NP_003144; P42226 |
| Omim ID: | 601512 |
| Immunogen: | Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding Y641of human STAT6. |
| Cross Reactivity: | Human. Other species not tested. |
| Packaging: | 0.1 mg of rabbit IgG |
| Uses: | This antibody is useful for Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections), ELISA. |
| Background: | The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. |
| Storage: | Store at +4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Host Name: | Rabbit |
| Application Summary: | Immunohistochemistry-Paraffin, ELISA |
| Species Summary: | Hu |
| Alternate Names: | anti-D12S1644 antibody, anti-IL-4-STAT antibody, anti-STAT6B antibody, anti-STAT6C antibody |
| Package Size: | 0.1 mg |
| Preservative: | 0.09% sodium azide. |
| Phosphorylated: | Tyr641 |
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