| CatalogCode: | PAB0615 |
| ProductName: | STAT3 Antibody |
| Product Description: | Rabbit Polyclonal anti-STAT3 - signal transducer and activator of transcription 3 (acute-phase response factor) [Ser727] |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S727 of human STAT3. |
| CrossReactivity: | Human. Other species not tested. |
| Packaging: | 0.1 mg of rabbit IgG |
| Uses: | This antibody is useful for Western Blot (Tissue lysate), Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections), ELISA. |
| Background: | The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described. |
| Storage: | Store at +4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Host_Name: | Rabbit |
| ListPrice: | 295 |
| AppSummary: | WB, IHC-P, ELISA |
| SpeciesSummary: | Hu |
| ALTnames: | APRF antibody, anti-FLJ20882 antibody, anti-MGC16063 |
| ProteinTarget: | signal transducer and activator of transcription 3 (acute-phase response factor) |
| PackageSize: | 0.1 mg |
| Phosphorylated: | Ser727 |
| NotesMain: | This antibody is available only in North America and is supplied by Abnova If in stock in Taiwan. delivery is 10-14 days. If not in stock. lead times can be extended. We will inform you of any extended delays within 48 hours.The immunizing protein is |
| Gene_Id: | 6774 |
| Gene_Symbol: | STAT3 |
| Ref_Sqnce: | NP_644805; P40763 |
| Omim_ID: | 102582 PAB0617 |
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