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| Catalog Code: | PAB0493 |
| Product Name: | IKBKG Phosphospecific Antibody |
| Product Description: | Rabbit Polyclonal anti-IKBKG - inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma [Ser43] |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Gene ID: | 8517 |
| Gene Symbol: | IKBKG |
| Reference Sequence: | NP_003630; Q9Y6K9 |
| Omim ID: | 300248 |
| Immunogen: | Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S43 of human IKBKG. |
| Cross Reactivity: | Human. Other species not tested. |
| Packaging: | 0.1 mg of rabbit IgG |
| Uses: | This antibody is useful for Western Blot (Cell lysate), Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections), ELISA. |
| Background: | Familial incontinentia pigmenti (IP) is a genodermatosis that segregates as an X-linked dominant disorder and is usually lethal prenatally in males (The International Incontinentia Pigmenti Consortium, 2000 [PubMed 10839543]). In affected females it causes highly variable abnormalities of the skin, hair, nails, teeth, eyes, and central nervous system. The prominent skin signs occur in 4 classic cutaneous stages: perinatal inflammatory vesicles, verrucous patches, a distinctive pattern of hyperpigmentation, and dermal scarring. Cells expressing the mutated X chromosome are eliminated selectively around the time of birth, so females with IP exhibit extremely skewed X-inactivation. Familial incontinentia pigmenti is caused by mutations in the NEMO gene and is here referred to as IP2, or 'classical' incontinentia pigmenti. Sporadic incontinentia pigmenti, the so-called IP1, which maps to Xp11, is categorized as hypomelanosis of Ito (MIM 300337).[supplied by OMIM] |
| Storage: | Store at +4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Host Name: | Rabbit |
| Application Summary: | Western Blot, Immunohistochemistry-Paraffin, ELISA |
| Species Summary: | Hu |
| Alternate Names: | AMCBX1 antibody, anti-FIP-3 antibody, anti-FIP3 antibody, anti-Fip3p antibody, anti-IKK-gamma antibody, anti-IP antibody, anti-IP1 antibody, anti-IP2 antibody, anti-IPD2 antibody, anti-NEMO |
| Package Size: | 0.1 mg |
| Preservative: | 0.09% sodium azide. |
| Phosphorylated: | Ser43 |
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