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| Catalog Code: | PAB0471 |
| Product Name: | FGFR1 Phosphospecific Antibody |
| Product Description: | Rabbit Polyclonal anti-FGFR1 - fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome) [Tyr654] |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Gene ID: | 2260 |
| Gene Symbol: | FGFR1 |
| Reference Sequence: | NP_075598; P11362 |
| Omim ID: | 136350 |
| Immunogen: | Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding Y653 and Y654 of human FGFR1. |
| Cross Reactivity: | Human. Other species not tested. |
| Packaging: | 0.1 mg of rabbit IgG |
| Uses: | This antibody is useful for Western Blot (Tissue lysate), Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections), ELISA. |
| Background: | The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. |
| Storage: | Store at +4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Host Name: | Rabbit |
| Application Summary: | Western Blot, Immunohistochemistry-Paraffin, ELISA |
| Species Summary: | Hu |
| Alternate Names: | anti-BFGFR antibody, anti-CD331 antibody, anti-CEK antibody, anti-FGFBR antibody, anti-FLG antibody, anti-FLT2 antibody, anti-HBGFR antibody, anti-KAL2 antibody, anti-N-SAM antibody |
| Package Size: | 0.1 mg |
| Preservative: | 0.09% sodium azide. |
| Phosphorylated: | Tyr654 |
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