| CatalogCode: | | PAB0467 |
| ProductName: | | FAS Antibody |
| Product Description: | | Rabbit Polyclonal anti-FAS - Fas (TNF receptor superfamily, member 6) [Tyr291] |
| Clonality: | | Polyclonal |
| Immunogen: | | Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding Y291 of human FAS. |
| CrossReactivity: | | Human. Other species not tested. |
| Packaging: | | 0.1 mg of rabbit IgG |
| Uses: | | This antibody is useful for ELISA, Dot Blot (peptide). |
| Background: | | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. At least eight alternatively spliced transcript variants encoding seven distinct isoforms have been described. The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. |
| Storage: | | Store at +4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Host_Name: | | Rabbit |
| ListPrice: | | 295 |
| AppSummary: | | ELISA, DB |
| SpeciesSummary: | | Hu |
| ALTnames: | | anti-ALPS1A antibody, anti-APO-1 antibody, anti-APT1 antibody, anti-CD95 antibody, anti-FAS1 antibody, anti-FASTM antibody, anti-TNFRSF6 antibody |
| ProteinTarget: | | Fas (TNF receptor superfamily, member 6) |
| PackageSize: | | 0.1 mg |
| Phosphorylated: | | Tyr291 |
| NotesMain: | | This antibody is available only in North America and is supplied by Abnova If in stock in Taiwan. delivery is 10-14 days. If not in stock. lead times can be extended. We will inform you of any extended delays within 48 hours.The immunizing protein is |
| Gene_Id: | | 355 |
| Gene_Symbol: | | FAS |
| Ref_Sqnce: | | NP_000034; P25445 |
| Omim_ID: | | 134637 H00000355-B01 |
| more information: | | company product webpage |