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| Catalog Code: | PAB0446 |
| Product Name: | CRK Phosphospecific Antibody |
| Product Description: | Rabbit Polyclonal anti-CRK - v-crk sarcoma virus CT10 oncogene homolog (avian) [Ser41] |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Gene ID: | 1398 |
| Gene Symbol: | CRK |
| Reference Sequence: | NP_005197; Q96GA9 |
| Omim ID: | 164762 |
| Immunogen: | Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S41 of human CRK. |
| Cross Reactivity: | Human. Other species not tested. |
| Packaging: | 0.1 mg of rabbit IgG |
| Uses: | This antibody is useful for ELISA, Dot Blot (peptide). |
| Background: | This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. |
| Storage: | Store at +4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Host Name: | Rabbit |
| Application Summary: | ELISA, Dot Blot |
| Species Summary: | Hu |
| Alternate Names: | anti-CRKII antibody |
| Package Size: | 0.1 mg |
| Preservative: | 0.09% sodium azide. |
| Phosphorylated: | Ser41 |
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more information: | company product webpage |