| CatalogCode: | | PAB0401 |
| ProductName: | | ABL1 Antibody |
| Product Description: | | Rabbit Polyclonal anti-ABL1 - v-abl Abelson murine leukemia viral oncogene homolog 1 [Ser588] |
| Clonality: | | Polyclonal |
| Immunogen: | | Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S588 of human ABL1. |
| CrossReactivity: | | Human. Other species not tested. |
| Packaging: | | 0.1 mg of rabbit IgG |
| Uses: | | This antibody is useful for Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections), ELISA. |
| Background: | | The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. |
| Storage: | | Store at +4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Host_Name: | | Rabbit |
| ListPrice: | | 295 |
| AppSummary: | | IHC-P, ELISA |
| SpeciesSummary: | | Hu |
| ALTnames: | | anti-RP11-83J21.1 antibody, anti-ABL antibody, anti-JTK7 antibody, anti-bcr/abl antibody, anti-c-ABL antibody, anti-p150 antibody, anti-v-abl antibody |
| ProteinTarget: | | v-abl Abelson murine leukemia viral oncogene homolog 1 |
| PackageSize: | | 0.1 mg |
| Phosphorylated: | | Ser588 |
| NotesMain: | | This antibody is available only in North America and is supplied by Abnova If in stock in Taiwan. delivery is 10-14 days. If not in stock. lead times can be extended. We will inform you of any extended delays within 48 hours.The immunizing protein is |
| Gene_Id: | | 25 |
| Gene_Symbol: | | ABL1 |
| Ref_Sqnce: | | NP_009297; Q17R61 |
| Omim_ID: | | 189980 PAB0396 |
| more information: | | company product webpage |