| Catalog Code: | NSB955 |
| Product Type: | Primary Antibody |
| Product Name: | PKC beta 1 + PKC beta 2 Antibody |
| List Price: | 310 |
| Clonality: | Polyclonal |
| Gene ID: | 5330 |
| Host: | Rabbit |
| Isotype: | IgG |
| Product Description: | Rabbit Polyclonal anti-PKC beta 1 + PKC beta 2 [Thr500] |
| Phosphorylated: | Thr500 |
| Cross Reactivity: | Cross-reacts with Human.Expected to cross-react with Mouse and Rat due to sequence homology.Not yet tested in other species. |
| Species Summary: | Hu |
| Background: | Protein Kinase C beta (PKC beta) is an 80 kDa member of the conventional group (cPKCs: sensitive to diacylglycerol, phosphotidylserine and phorbol esters) of the PKC family of serine/threonine kinases that are involved in a wide range of physiological pro |
| Alternate Names: | anti-PKCB1 antibody, anti-PKCB2 antibody, anti-PRKCB1 antibody, anti-Protein kinase C beta 1 antibody, anti-Protein kinase C beta 2 antibody |
| Immunogen: | Synthetic phosphopeptide derived from a region of human PKC beta 1 & 2 that contains threonine 500. |
| Localization: | Cytoplasmic and Plasma membrane |
| Specificity: | This antibody cross-reacts with PKC alpha [pT497] (88% homologous) and partially cross-reacts with PKC gamma [pT514] (63% homologous) and epsilon [pT566] (75% homologous), as determined by peptide competition experiments. |
| Purity: | Immunogen affinity purified |
| Buffer: | Preservative: 0.05% Sodium AzideConstituents: 50% Glycerol, PBS, 1mg/ml BSA. pH 7.3 |
| Packaging: | 100 microlitres |
| Package Size: | 0.1 ml |
| Uses: | WB: Use at a dilution of 1/1000. Detects a band of approximately 80 kDa. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Application Summary: | WB |
| General References: | General / background references:Newton AC Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm. Biochem J 370:361-71 (2003). Yoshida M et al. Involvement of PKC betaII in anti-proliferating action of a new anti |