| CatalogCode: | NSB948 |
| ProductName: | GATA4 Antibody |
| Product Description: | Rabbit Polyclonal anti-GATA4 [Ser105] |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide (Human) derived from a region of GATA 4 that contains serine 105. |
| CrossReactivity: | Cross-reacts with Mouse. Expected to cross-react with Chicken (100% identity with immunogen), Human (100% identity with immunogen), Rat (100% identity with immunogen) due to sequence homology. Not yet tested in other species. |
| Packaging: | 0.1 ml Immunogen affinity purified Rabbit antisera. |
| Uses: | WB: Use at a concentration of 0.1 - 1.0 ug/ml. Predicted molecular weight: 46 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. |
| Control: | Phenylephrine (PE)-stimulated rat cardiomyocytes, transfected with mouse GATA 4. |
| Background: | GATA4 is a 46 kDa member of the GATA family of zinc finger containing transcription factors that is involved in the development of cardiac hypertrophy and remodeling, and plays a critical role in regulating basal and agonist or stress induced gene expression in cardiac and smooth muscle cell types. GATA4 contains a conserved MAPK phosphorylation site at serine 105 within the transcriptional activation domain. Serine 105 of GATA4 is phosphorylated in response to agonist stimulation through MEK 1 ERK1 / 2, and weakly through JNK or p38 MAPKs. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | Preservative: 0.05% Sodium Azide Constituents: PBS, 1mg/ml BSA (IgG, protease free). pH 7.3 |
| ListPrice: | 325 |
| AppSummary: | WB |
| SpeciesSummary: | Mu |
| ALTnames: | anti-GATA 4 antibody, anti-GATA binding protein 4 antibody, anti-GATA-4 antibody, anti-MGC126629 antibody, anti-Transcription factor GATA 4 antibody |
| ProteinTarget: | GATA4 phospho S105 |
| PackageSize: | 0.1 ml |
| GeneralRef: | General / background references:Kitta K et al. Hepatocyte growth factor induces GATA-4 phosphorylation and cell survival in cardiac muscle cells. J Biol Chem 278:4705-12 (2003). Dentice M et al. The Different Cardiac Expression of the Type 2 Iodothyronine Deiodinase Gene between Human and Rat Is Related to the Differential Response of the dio2 Genes to Nkx-2.5 and GATA-4 Transcription Factors. Mol Endocrinol 17:1508-21 (2003). Clement SA et al. Roles of protein kinase C and alpha-tocopherol in regulation of signal transduction for GATA-4 phosphorylation in HL-1 cardiac muscle cells. Free Radic Biol Med 32:341-9 (2002). |
| Phosphorylated: | Ser105 |
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