| Catalog Code: | NSB910 |
| Product Type: | Primary Antibody |
| Product Name: | Hck Antibody |
| List Price: | 310 |
| Clonality: | Polyclonal |
| Gene ID: | 3055 |
| Host: | Rabbit |
| Isotype: | IgG |
| Product Description: | Rabbit Polyclonal anti-Hck [Tyr207/Ser211] |
| Phosphorylated: | Tyr207/Ser211 |
| Cross Reactivity: | Cross-reacts with Rat.Expected to cross-react with Human (92% identity with immunogen), Mouse (100% identity with immunogen) due to sequence homology.Not yet tested in other species. |
| Species Summary: | Rt |
| Background: | Hck is a member of the Src family of non-receptor tyrosine kinases involved in the modulation of a wide variety of normal and pathogenic cellular processes including growth, development, differentiation, and carcinogenesis. These proteins contain a consen |
| Immunogen: | The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of mouse Hck that contains tyrosine 207 and serine 209 (tyrosine 209 and serine 211 in human). |
| Specificity: | There is some cross-reactivity with Src family kinases Lck and Lyn, but the antibody does not react with Src, Fyn, or Yes. |
| Purity: | Immunogen affinity purified |
| Buffer: | Preservative: 0.05% Sodium AzideConstituents: PBS, 1mg/ml BSA (IgG, protease free). pH 7.3 |
| Packaging: | 100 microlitres |
| Package Size: | 0.1 ml |
| Concentration: | 0.5 mg/ml |
| Uses: | WB: Use at a concentration of 0.35 - 1.0 ug/ml. Predicted molecular weight: 63 kDa. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Application Summary: | WB |
| General References: | General / background references:Young MA et al. Dynamic coupling between the SH2 and SH3 domains of c-Src and Hck underlies their inactivation by C-terminal tyrosine phosphorylation. Cell 105:115-26 (2001). Hubbard SR & Till JH Protein ty |