| Catalog Code: | NSB909 |
| Product Type: | Primary Antibody |
| Product Name: | Dab1 Antibody |
| List Price: | 310 |
| Clonality: | Polyclonal |
| Gene ID: | 1600 |
| Host: | Rabbit |
| Isotype: | IgG |
| Product Description: | Rabbit Polyclonal anti-Dab1 [Ser491] |
| Phosphorylated: | Ser491 |
| Cross Reactivity: | Cross-reacts with Human and Mouse.Expected to cross-react with Chicken (100% identity with immunogen) and Rat (100% identity with immunogen) due to sequence homology.Not yet tested in other species. |
| Species Summary: | Hu, Mu |
| Background: | Disabled 1 (Dab1) is an 80 kDa protein that is encoded by the Disabled-1 gene locus which is mutated in scrambler and yotari mutant mice. Phenotypically, the mutation of this gene produces motor defects and ataxia, disruption of neuronal migration, and se |
| Immunogen: | Synthetic phosphopeptide derived from the region of human Dab1 that contains serine 491. |
| Purity: | Protein A purified |
| Buffer: | Preservative: 0.05% Sodium AzideConstituents: 50% Glycerol, PBS, 1mg/ml BSA. pH 7.3 |
| Packaging: | 100 microlitres |
| Package Size: | 0.1 ml |
| Uses: | WB: Use at a dilution of 1/1000. Detects a band of approximately 80 kDa. When examining phosphorylation of endogenous Dab1 protein we recommend that Dab1 protein first be immunoprecipitated.Not tested in other applications.Optimal dilutions/concentrations |
| Application Summary: | WB |
| General References: | General / background references:Arnaud L et al. Fyn tyrosine kinase is a critical regulator of disabled-1 during brain development. Curr Biol 13:9-17 (2003). Beffert U et al. Reelin-mediated signaling locally regulates protein kinase B/Ak |