| CatalogCode: | NSB876 |
| ProductName: | Integrin beta 3 Antibody |
| Product Description: | Rabbit Polyclonal anti-Integrin beta 3 [Tyr773] |
| Clonality: | Polyclonal |
| Immunogen: | The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of human Integrin beta 3 receptor that contains tyrosine 773 (based on Swiss Protein database, accession number P05106). The sequence is conserved in human, mouse and rat. |
| CrossReactivity: | Cross-reacts with Human.Expected to cross-react with Chicken (94% identity with immunogen), Mouse (100% identity with immunogen), Rat (100% identity with immunogen), Xenopus laevis (88% identity with immunogen) due to sequence homology.Not yet tested in other species. |
| Packaging: | 0.1 ml |
| Uses: | WB: Use at a concentration of 0.1 - 1.0 ug/ml. Predicted molecular weight: 130 kDa. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Cell Membrane |
| Control: | K562 cells transfected with human Integrin alpha and wild-type (WT) or mutant (Y773F) human Integrin |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | Preservative: 0.05% Sodium AzideConstituents: PBS, 1mg/ml BSA (IgG, protease free). pH 7.3 |
| ListPrice: | 325 |
| AppSummary: | WB |
| SpeciesSummary: | Hu |
| ProteinTarget: | Integrin beta 3 |
| PackageSize: | 0.1 ml |
| GeneralRef: | General / background references:Boettiger D et al. Distinct ligand-binding modes for integrin alpha(v)beta(3)-mediated adhesion to fibronectin versus vitronectin. J Biol Chem 276:31684-90 (2001). Cukierman E et al. Taking cell-matrix adhesions to the third dimension. Science 294:1708-12 (2001). Maile LA et al. Structural analysis of the role of the beta 3 subunit of the alpha V beta 3 integrin in IGF-I signaling. J Cell Sci 114:1417-25 (2001). Sanjay A et al. Cbl associates with Pyk2 and Src to regulate Src kinase activity, alpha(v)beta(3) integrin-mediated signaling, cell adhesion, and osteoclast motility. J Cell Biol 152:181-95 (2001). |
| Phosphorylated: | Tyr773 |