| Catalog Code: | NSB844 |
| Product Type: | Primary Antibody |
| Product Name: | Lck Antibody |
| List Price: | 310 |
| Clonality: | Polyclonal |
| Gene ID: | 3932 |
| Host: | Rabbit |
| Isotype: | IgG |
| Product Description: | Rabbit Polyclonal anti-Lck [Ser192] |
| Phosphorylated: | Ser192 |
| Cross Reactivity: | Cross-reacts with Human.Expected to cross-react with Chicken (79% identity with immunogen), Mouse (100% identity with immunogen) due to sequence homology.Not yet tested in other species. |
| Species Summary: | Hu |
| Background: | Lck (p56lck), a member of the Src family of non-receptor tyrosine protein kinases, is expressed predominantly in T cells. Lck function is critical both for T cell development in the thymus and activation of mature T cells in the periphery by antigen. The |
| Alternate Names: | anti-Lck p56 antibody, anti-Lymphocyte Specific Protein Tyrosine Kinase antibody, anti-Membrane associated protein tyrosine kinase antibody, anti-Oncogene lck antibody, anti-P56 LCK antibody, anti-Proto oncogene tyrosine protein kinase LCK antibody, anti- |
| Immunogen: | Synthetic peptide (Human) derived from the region of human Lck that contains tyrosine 192 (based on Swiss Protein database, accession number P06239). The sequence is conserved in human and mouse. |
| Localization: | Cytoplasmic |
| Specificity: | Lck (79% homologous), Hck (79% homologous) and Lyn (93% homologous) have not been tested. |
| Purity: | Immunogen affinity purified |
| Buffer: | Preservative: 0.05% Sodium AzideConstituents: PBS, 1mg/ml BSA (IgG, protease free). pH 7.4 |
| Packaging: | 100 microlitres |
| Package Size: | 0.1 ml |
| Concentration: | 0.5 mg/ml |
| Uses: | WB: Use at a concentration of 0.1 - 1.0 ug/ml. Predicted molecular weight: 60 kDa. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Application Summary: | WB |
| General References: | General / background references:Fujimaki W et al. Functional uncoupling of T-cell receptor engagement and Lck activation in anergic human thymic CD4+ T cells. J Biol Chem 276:17455-60 (2001). Ellery JM et al. Activation of the interleukin |