| Catalog Code: | NSB824 |
| Product Type: | Primary Antibody |
| Product Name: | IRS 1 Antibody |
| List Price: | 310 |
| Clonality: | Polyclonal |
| Gene ID: | 3667 |
| Host: | Rabbit |
| Isotype: | IgG |
| Product Description: | Rabbit Polyclonal anti-IRS 1 [Tyr1229] |
| Phosphorylated: | Tyr1229 |
| Cross Reactivity: | Cross-reacts with Human.Expected to cross-react with Chicken (93% identity with immunogen), Mouse (86% identity with immunogen), Rat (86% identity with immunogen) due to sequence homology.Not yet tested in other species. |
| Species Summary: | Hu |
| Background: | Insulin Receptor Substrate 1 (IRS 1) is a 165 kDa multi-phosphorylated cytoplasmic docking protein involved in the regulation of metabolism and proliferation by insulin, IL-4, and other cytokines. Insulin binding to the insulin receptor activates the cata |
| Alternate Names: | anti-Insulin Receptor Substrate 1 antibody, anti-IRS 1 antibodyanti-IRS1 antibody |
| Immunogen: | Synthetic peptide (Human) derived from a region of IRS 1 that contains tyrosine 1229. |
| Purity: | Immunogen affinity purified |
| Buffer: | Preservative: 0.05% Sodium AzideConstituents: PBS, 1mg/ml BSA (IgG, protease free). pH 7.4 |
| Packaging: | 100 microlitres |
| Package Size: | 0.1 ml |
| Concentration: | 0.35 mg/ml |
| Uses: | WB: Use at a concentration of 0.1 - 1.0 ug/ml. Predicted molecular weight: 165 kDa. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Application Summary: | WB |
| General References: | General / background references:Xiao H et al. Specificity of interleukin-2 receptor gamma chain superfamily cytokines is mediated by insulin receptor substrate-dependent pathway. J Biol Chem 277:8091-8 (2002). Aguirre V et al. Phosphoryla |