| Catalog Code: | NSB802 |
| Product Type: | Primary Antibody |
| Product Name: | Insulin Receptor Antibody |
| List Price: | 310 |
| Clonality: | Polyclonal |
| Gene ID: | 3643 |
| Host: | Rabbit |
| Isotype: | IgG |
| Product Description: | Rabbit Polyclonal anti-Insulin Receptor [Tyr1158] |
| Phosphorylated: | Tyr1158 |
| Cross Reactivity: | Cross-reacts with Human.Expected to cross-react with Mouse (100% identity with immunogen), Rat (100% identity with immunogen) due to sequence homology.Not yet tested in other species. |
| Species Summary: | Hu |
| Background: | Biological actions of insulin and IGF1 are mediated by their respective cell surface receptors, both of which are receptor tyrosine kinases that regulate multiple signaling pathways through activation of a series of phosphorylation cascades. The Insulin R |
| Alternate Names: | anti-IGFR1 antibody, anti-Insulin growth factor 1 receptor antibody, anti-CD221 antibody |
| Immunogen: | Synthetic phosphopeptide derived from the region of Insulin Receptor that contains tyrosine 1158. The corresponding residue in the IGF1R is 1131. |
| Localization: | Type I membrane protein |
| Purity: | Immunogen affinity purified |
| Buffer: | Preservative: 0.05% Sodium AzideConstituents: 50% Glycerol, PBS, 1mg/ml BSA. pH 7.3 |
| Packaging: | 100 microlitres |
| Package Size: | 0.1 ml |
| Uses: | WB: Use at a dilution of 1/1000. Detects a band of approximately 120 kDa. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Application Summary: | WB |
| General References: | This product has been used in:Motley ED et al. Insulin-induced Akt activation is inhibited by angiotensin II in the vasculature through protein kinase C-alpha. Hypertension 41:775-80 (2003). Wick KR et al. Grb10 inhibits insulin-stimulate |