| CatalogCode: | NSB636 |
| ProductName: | PYK 2 Antibody |
| Product Description: | Rabbit Polyclonal anti-PYK 2 [Tyr579/Tyr580] |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide (Human) derived from the region of human Pyk 2 that contains tyrosines 579 and 580. The sequence is conserved in human and rat. |
| Specificity: | Some cross-reactivity still may be experienced in cases where Focal Adhesion Kinase is overexpressed relative to PYK 2 within the same cell system. |
| CrossReactivity: | Cross-reacts with Human, Chicken and Rat.Not yet tested in other species. |
| Packaging: | 0.1 ml |
| Uses: | WB: Use at a concentration of 0.1 - 1.0 ug/ml. Predicted molecular weight: 116 kDa. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Control: | Vandate treated CEF cells expressing PYK 2 and plated on fibronectin. |
| Background: | Proline-rich/Ca2+ -activated tyrosine kinase (PYK 2, also known as RAFTK, CAK beta or Focal Adhesion Kinase 2) is a member of the Focal Adhesion Kinase family of non-receptor, proline-rich PTK's. PYK 2 signalling is initiated by a variety of extracellular stimuli including integrin ligation, CD surface marker ligation (e.g., CD3, CD28, TCR, VCAM), bioactive peptides, growth factors, cytokines, chemokines, and certain stress stimuli. PYK 2 is involved in the regulation of vesicular transport, osteoclastic bone resorption, modulation of ion channels, T- and B-cell receptor signaling and cell death. Phosphorylation of the catalytic domain tyrosines 579 and 580 results in maximum activation of PYK 2. Tyr579 and Tyr580 are phosphorylated by Src. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | Preservative: 0.05% Sodium AzideConstituents: PBS, 1mg/ml BSA (IgG, protease free). pH 7.4 |
| ListPrice: | 325 |
| AppSummary: | WB |
| SpeciesSummary: | Hu, Ch, Rt |
| ALTnames: | anti-FADK antibody, anti-FAK 2 antibody, anti-FAK antibody, anti-FAK1 antibody, anti-Focal Adhesion Kinase 2 antibody, anti-pp125FAK antibody, anti-Proline Rich Tyrosine Kinase 2 antibody, anti-Protein Tyrosine Kinase 2 Beta antibody, anti-PTK 2B antibody |
| ProteinTarget: | PYK 2 |
| PackageSize: | 0.1 ml |
| GeneralRef: | This product has been used in:Katagiri T et al. Protein-tyrosine kinase Pyk2 is involved in interleukin-2 production by Jurkat T cells via its tyrosine 402. J Biol Chem 275:19645-52 (2000). General / background references:Sorokin A et al. Protein-tyrosine kinase Pyk2 mediates endothelin-induced p38 MAPK activation in glomerular mesangial cells. J Biol Chem 276:21521-8 (2001). Ridyard MS & Sanders EJ Potential roles for focal adhesion kinase in development. Anat Embryol (Berl) 199:1-7 (1999). Berk BC Angiotensin II signal transduction in vascular smooth muscle: pathways activated by specific tyrosine kinases. J Am Soc Nephrol 10 Suppl 11:S62-8 (1999). |
| Phosphorylated: | Tyr579/Tyr580 |
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