| CatalogCode: | NSB609 |
| ProductName: | AKT Antibody |
| Product Description: | Rabbit Polyclonal anti-AKT |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic phosphopeptide (Human) (C terminal). |
| CrossReactivity: | Expected to cross-react with Human, Mouse and Rat (94% identity with immunogen) due to sequence homology. Expected to react with human AKT2 and AKT3.Not yet tested in other species. |
| Packaging: | 0.2 ml Immunogen affinity purified Rabbit antisera. |
| Uses: | WB: Use at a dilution of 1/1000. Predicted molecular weight: 58 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Cytoplasmic and Nuclear |
| Control: | 3T3L1 cell lysate. |
| Background: | AKT, also known as Protein Kinase B (PKB) or RAC alpha, is a 60 kDa serine/threonine kinase that plays an important role in multiple biological responses including metabolism, cell survival and growth by phosphorylating many proteins including GSK-3 alpha, caspase 9, BAD, and the Forkhead Transcription Factor. Akt is activated by PI3K, which in turn can interact with proteins like FAK thereby linking activation to the cytoskeleton. Akt/PKB is constitutively active in many types of human cancer, and contributes to tumor progression by promoting angiogenesis and cell invasiveness. Akt is fully activated by phosphorylation of threonine 308 by PDK1 and serine 473 by PDK2. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | Preservative: 0.05% Sodium Azide Constituents: 50% Glycerol, 1.0mg/ml BSA, PBS (Mg<sup>2+</ |
| ListPrice: | 325 |
| AppSummary: | WB |
| SpeciesSummary: | Hu, Mu |
| ALTnames: | anti-CAKT antibody, anti-Murine thymoma viral (vakt) oncogene homolog 1 antibody, anti-PKB Akt antibody, anti-PKB alpha antibody, anti-PKB antibody, anti-PKBalpha antibody, anti-PRKBA antibody, anti-RAC alpha serine/threonine protein kinase antibody, anti-RAC Serine/Threonine Protein Kinase antibody, anti-V AKT Murine Thymoma Viral Oncogene Homolog 1 antibody, anti-VAKT Murine Thymona Viral Oncogene 1 antibody, anti-RAC-PK-alpha antibody, anti-Protein kinase B antibody |
| ProteinTarget: | AKT |
| PackageSize: | 0.2 ml |
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