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| Catalog Code: | NSB572 |
| Product Name: | Rb Phosphospecific Antibody |
| Product Description: | Rabbit Polyclonal anti-Rb [Ser612] |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Concentration: | 0.25 mg/ml |
| Immunogen: | Synthetic peptide (Human) derived from a region of human Rb that contains serine 612 (based on Swiss Protein database, accession number P06400). |
| Cross Reactivity: | Cross-reacts with Human.Expected to cross-react with Chicken (87% identity with immunogen), Mouse (80% identity with immunogen), Rat (80% identity with immunogen) due to sequence homology.Not yet tested in other species. |
| Packaging: | 0.1 ml |
| Uses: | WB: Use at a concentration of 0.15 - 0.5 ug/ml. Predicted molecular weight: 106 kDa. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Nuclear |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | Preservative: 0.05% Sodium AzideConstituents: PBS, 1.0mg/ml BSA (IgG, protease free). pH 7.4 |
| Application Summary: | Western Blot |
| Species Summary: | Hu |
| Alternate Names: | anti-OSRC antibody, anti-P105RB antibody, anti-PP105 antibody, anti-PP110 antibody, anti-pRb antibody, anti-Retinoblastoma 1 antibody, anti-Retinoblastoma antibody, anti-Retinoblastoma associated protein antibody, anti-Retinoblastoma related osteosarcoma antibody, anti-Retinoblastoma susceptibility gene antibody |
| Package Size: | 0.1 ml |
| Phosphorylated: | Ser612 |
| General References: | General / background references:Brantley MA & Harbour JW The molecular biology of retinoblastoma. Ocul Immunol Inflamm 9:1-8 (2001). Tamrakar S et al. Role of pRB dephosphorylation in cell cycle regulation. Front Biosci 5:D121-37 (2000). Brown VD et al. Cumulative effect of phosphorylation of pRB on regulation of E2F activity. Mol Cell Biol 19:3246-56 (1999). Harbour JW et al. Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1. Cell 98:859-69 (1999). |
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