| Catalog Code: | NSB550 |
| Product Type: | Primary Antibody |
| Product Name: | IRS 1 Antibody |
| List Price: | 310 |
| Clonality: | Polyclonal |
| Gene ID: | 3667 |
| Host: | Rabbit |
| Isotype: | IgG |
| Product Description: | Rabbit Polyclonal anti-IRS 1 [Ser616] |
| Phosphorylated: | Ser616 |
| Cross Reactivity: | Cross-reacts with Human.Expected to cross-react with Mouse (100% identity with immunogen), Rat (100% identity with immunogen) due to sequence homology.Not yet tested in other species. |
| Species Summary: | Hu |
| Background: | Insulin Receptor Substrate 1 (IRS 1) is a 165 kDa multi-phosphorylated cytoplasmic docking protein involved in metabolic and proliferative signaling by insulin, IL-4, and other cytokines. IRS 1 functions to enhance growth hormone-induced proliferative sig |
| Alternate Names: | anti-Insulin Receptor Substrate 1 antibody, anti-IRS 1 antibodyanti-IRS1 antibody |
| Immunogen: | Synthetic peptide derived from a region of IRS 1 that contains serine 616. The sequence is conserved in human, mouse, and rat. |
| Purity: | Immunogen affinity purified |
| Buffer: | Constituents: PBS, 1.0mg/ml BSA (IgG, protease free). pH 7.4 |
| Packaging: | 0.1 ml Immunogen affinity purified Rabbit antisera. |
| Package Size: | 0.1 ml |
| Concentration: | 0.5 mg/ml |
| Uses: | WB: Predicted molecular weight: 165 kDa. |
| Application Summary: | WB |
| General References: | This product has been used in:Aguirre V et al. Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action. J Biol Chem 277:1531-7 (2002). Reiss K et al. Mechanisms o |