| CatalogCode: | NSB376 |
| ProductName: | STAT1 Antibody |
| Product Description: | Rabbit Polyclonal anti-STAT1 [Tyr701] |
| Clonality: | Polyclonal |
| Immunogen: | The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of mouse STAT1 that contains tyrosine 701. |
| CrossReactivity: | Mouse and rat, and to a lesser extent human STAT1. |
| Packaging: | 0.1 ml Immunogen affinity purified Rabbit antisera. |
| Uses: | This antibody is suitable for use in Western blotting. The recommended concentration for use in Western blotting is 1:1,000.*The optimal concentration should be determined for each specific application. |
| Control: | 3T3-L1 adipocytes +/- Leukemia Inhibitory Factor (LIF). |
| Background: | The signal transducer and activator of transcription (STAT) family of transcription factors is composed of seven family members (STATs 1, 2, 3, 4, 5A, 5B and 6) that are involved in many cell processes (apoptosis, anti-apoptosis, cell differentiation and proliferation), depending upon the cell type. STATs are activated by ligand binding to cytokine receptors and other types of receptors, those receptors associating with Janus kinase (JAK) family members that phosphorylate STAT protein, causing it to translocate to the nucleus. In the nucleus, phosphorylated STAT protein binds to DNA and regulates the transcription of particular genes. Phosphorylation on tyrosine 701 by JAK1&2 is essential for STAT1 dimer formation, nuclear translocation and DNA binding activity. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| ListPrice: | 325 |
| AppSummary: | WB |
| SpeciesSummary: | Mu, Rt, Hu(+/-) |
| ALTnames: | anti-ISGF 3 antibody, anti-Signal Transductor and Activator of Transcription 1 antibody |
| ProteinTarget: | STAT1, mouse (phospho Y701) |
| PackageSize: | 0.1 ml |
| GeneralRef: | Schindler, C.W. (2002) Series introduction. JAK-STAT signaling in human disease. J. Clin. Invest. 109(9):1133-1137. Ortmann, R.A., et al. (2000) Janus kinases and signal transducers and activators of transcription: their roles in cytokine signaling, development and immunoregulation. Arthritis Res. 2(1):16-32. Ihle, J.N. (1996) STATs: signal transducers and activators of transcription. Cell 84(3):331-334. Wen, Z. (1995) Maximal activation of transcription by STAT1 and STAT3 requires both tyrosine and serine phosphorylation. Cell 82(2):241-250. |
| Phosphorylated: | Tyr701 |
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