| CatalogCode: | NSB326 |
| ProductName: | Phospholipase D2 Antibody |
| Product Description: | Rabbit Polyclonal anti-Phospholipase D2 |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide (Mouse). |
| CrossReactivity: | Cross-reacts with Mouse. Not yet tested in other species. |
| Packaging: | 0.1 mg Immunogen affinity purified Rabbit antisera. |
| Uses: | WB: Use at a dilution of 1/100 - 1/2000. Detects a band of approximately 105 kDa (predicted molecular weight: 112 kDa). Due to the low level of expression of this protein it is suggested that the protein is immunoprecipitated before Western blotting. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. |
| Background: | Activation of phospholipase D results in the generation of second messengers, phosphatidic acid and diglycerides, and appears to be involved in secretion, vesicle trafficking, mitosis and meiosis. In leukocytes, phospholipase D regulates cytoskeletal-dependent antimicrobial responses such as phagocytosis and oxidant generation. The mechanisms that regulate phospholipase D2 are not known. This isoform is unaffected by the activators of phospholipase D1. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | Preservative: 0.05% Sodium Azide Constituents: 1mg/ml BSA, PBS Ca<sup>2+</sup>and Mg< |
| ListPrice: | 325 |
| AppSummary: | WB |
| SpeciesSummary: | Mu |
| ALTnames: | anti-Choline phosphatase 2 antibody, anti-Phosphatidylcholine-hydrolyzing phospholipase D2 antibody, anti-PLD2 antibody |
| ProteinTarget: | Phospholipase D2 |
| PackageSize: | 0.1 mg |
| GeneralRef: | This product has been used in:Sciorra VA & Morris AJ Sequential actions of phospholipase D and phosphatidic acid phosphohydrolase 2b generate diglyceride in mammalian cells. Mol Biol Cell 10:3863-76 (1999). General / background references:Colley WC et al. Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization. Curr Biol 7:191-201 (1997). |