| CatalogCode: | NSB230 |
| ProductName: | ZAP70 Antibody |
| Product Description: | Rabbit Polyclonal anti-ZAP70 [Tyr292] |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide derived from a region of human ZAP70 that contains tyrosine 292 (unfortunately, the amino acid sequence is considered to be commercially sensitive) |
| CrossReactivity: | Cross-reacts with Human.Expected to cross-react with Mouse due to sequence homology.Not yet tested in other species. |
| Packaging: | 0.1 ml |
| Uses: | WB: Use at a dilution of 1/1000. Predicted molecular weight: 74.3 kDa. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Cytoplasmic |
| Control: | Jurkat cells treated with hydrogen peroxide. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | Preservative: 0.05% Sodium AzideConstituents: Dulbecco's PBS without magnesium and calcium, 50% Glyc |
| ListPrice: | 325 |
| AppSummary: | WB |
| SpeciesSummary: | Hu |
| ALTnames: | anti-70 kDa zeta associated protein antibody, anti-Selective T cell defect antibody, anti-SRK antibody, anti-STD antibody, anti-Syk related tyrosine kinase antibody, anti-Truncated ZAP kinase antibody, anti-Tyrosine protein kinase ZAP70 antibody, anti-TZK antibody, anti-Zeta chain associated protein kinase 70kDa isoform 1 antibody, anti-Zeta chain associated protein kinase 70kDa isoform 2 antibody |
| ProteinTarget: | ZAP70 (phospho Y292) |
| PackageSize: | 0.1 ml |
| GeneralRef: | General / background references:Orchard JA et al. ZAP-70 expression and prognosis in chronic lymphocytic leukaemia. Lancet 363:105-11 (2004). Sakaguchi N et al. Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice. Nature 426:454-60 (2003). Bottini N et al. Activation of ZAP-70 through specific dephosphorylation at the inhibitory Tyr-292 by the low molecular weight phosphotyrosine phosphatase (LMPTP). J Biol Chem 277:24220-4 (2002). Magnan A et al. T cell development and T cell responses in mice with mutations affecting tyrosines 292 or 315 of the ZAP-70 protein tyrosine kinase. J Exp Med 194:491-505 (2001). |
| Phosphorylated: | Tyr292 |
| NotesMain: | Centrifuge before opening to settle contents. |