| Catalog Code: | NSB1100 |
| Product Type: | Primary Antibody |
| Product Name: | PRAS40 Antibody |
| List Price: | 310 |
| Clonality: | Polyclonal |
| Gene ID: | 84335 |
| Host: | Rabbit |
| Product Description: | Rabbit Polyclonal anti-PRAS40 [Thr246] |
| Phosphorylated: | Thr246 |
| Cross Reactivity: | Human and mouse PRAS40. |
| Species Summary: | Hu, Mu |
| Background: | Proline-Rich Akt Substrate (PRAS40) is a 40 kDa substrate of Akt. Akt and PRAS40 can be found in the phosphoinositide 3-kinase (PI3K) pathway, which plays a role in glucose uptake, cell growth, and apoptosis inhibition. PRAS40 is a 14-3-3 binding protein |
| Alternate Names: | anti-AKT1 substrate 1 (proline rich) antibody, anti-AKT1S1 antibody, anti-Lobe antibody, anti-MGC2865 antibody, anti-Nuclear pore glycoprotein p62 antibody, anti-NUP62 antibody, anti-Proline rich akt substrate antibody |
| Immunogen: | The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of human PRAS40 that contains threonine 246. |
| Packaging: | 0.1 ml Rabbit antisera. |
| Package Size: | 0.1 ml |
| Concentration: | 1 mg/ml |
| Uses: | WB: Use at a dilution of 1/1000. Not tested in other applications. The optimal dilution should be determined by the end user. |
| Application Summary: | WB |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| General References: | Kovacina, K.S., et al. (2003) Identification of a proline-rich Akt substrate as a 14-3-3 binding partner. J. Biol. Chem. 278:10189-10194. Cantley, L.C. (2002) The phosphoinositide 3-kinase pathway. Science. 296(5573):1655-1657.Lizcano, J.M. and D.R. Aless |