| Catalog Code: | NSB1076 |
| Product Type: | Primary Antibody |
| Product Name: | LIMK 1/2 Antibody |
| List Price: | 310 |
| Clonality: | Polyclonal |
| Gene ID: | 3984 |
| Host: | Rabbit |
| Product Description: | Rabbit Polyclonal anti-LIMK 1/2 [Thr507/Tyr508] |
| Phosphorylated: | Thr507/Tyr508 |
| Cross Reactivity: | Human LIMK1/2. Mouse, rat and frog LIMK1/2 have not been tested, but are expected to react. |
| Species Summary: | Hu |
| Background: | The Lin-11, Is1-1 and Mec-3 kinases 1 and 2 (LIMK1 [72 kDa] and LIMK2 [65 kDa]) are serine/threonine kinases that are involved in actin cytoskeletal reorganization, cell growth regulation and tumor supression. LIMK1/2 are activated by various extracellula |
| Alternate Names: | EC 2.7.1.37 antibody, LIM domain containing protein kinase antibody, LIM domain kinase 1 antibody, LIMK 1 antibody |
| Immunogen: | The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of human LIMK1 that contains tyrosine 507 and threonine 508 (tyrosine 504 and threonine 505 in LIMK2). The LIMK1 sequence is conserved in mouse and rat, and |
| Localization: | Cytoplasmic |
| Specificity: | This antibody is specific for LIM Kinase only when phosphorylated at threonine 507/508. |
| Purity: | Affinity purified |
| Buffer: | PBS (without Mg2+ and Ca2+), pH 7.3 (+/- 0.1), 50% glycerol, with 1.0 mg/mL BSA (IgG, protease free) |
| Packaging: | 0.1 ml Affinity purified Rabbit antisera. |
| Package Size: | 0.1 ml |
| Uses: | The antibody has been used for Western blotting, where a band is seen around 75 kDa. |
| Application Summary: | WB |
| General References: | Davila, M., et al. (2003) LIM kinase 1 is essential for the invasive growth of prostate epithelial cells: implications in prostate cancer. J. Biol. Chem. 278(38):36868-36875. Sumi, T., et al. (2002) Mitosis-dependent phosphorylation and activation of LIM- |