| Catalog Code: | NSB1022 |
| Product Type: | Primary Antibody |
| Product Name: | Paxillin Antibody |
| List Price: | 310 |
| Clonality: | Polyclonal |
| Gene ID: | 5829 |
| Host: | Rabbit |
| Product Description: | Rabbit Polyclonal anti-Paxillin [Ser126] |
| Phosphorylated: | Ser126 |
| Cross Reactivity: | Mouse and human (100% homologous) paxillin. Chicken (100% homologous) has not been tested, but is expected to react. |
| Species Summary: | Hu, Mu |
| Background: | Paxillin is a 68 kDa cytoskeletal adapter protein involved in organization and function of focal adhesions, which are critical to cell adhesion and migration. These cellular events in turn play a role in a wide variety of processes including embryogenesis |
| Alternate Names: | anti-FLJ23042 antibody, anti-PXN antibody |
| Immunogen: | The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of human paxillin that contains serine 126. The sequence is conserved in mouse and chicken. |
| Packaging: | 0.1 ml of epitope-affinity purified rabbit antisera in PBS, pH 7.4 (without Mg2+ and Ca2+), pH 7.3 (+/- 0.1), 50% glycerol, with 1.0 mg/mL BSA (IgG, protease free) as a carrier. Contains 0.02% sodium azide (Caution: sodium azide is a poisonous and hazardo |
| Package Size: | 0.1 ml |
| Uses: | This antibody is suitable for use in Western blotting. The recommended concentration for use in Western blotting is 1:1,000. *The optimal concentration should be determined for each specific application. |
| Application Summary: | WB |
| General References: | Woodrow, M.A., et al. (2003) Ras-induced serine phosphorylation of the focal adhesion protein paxillin is mediated by the Raf-->MEK-->ERK pathway. Exp. Cell. Res. 287(2):325-338.Schaller, M.D. (2001) Paxillin: a focal adhesion-associated adaptor protein. |