| CatalogCode: | | NLS7403 |
| ProductName: | | Traf2 And NCK-Interacting Kinase Antibody |
| Product Description: | | Rabbit Polyclonal anti-Traf2 And NCK-Interacting Kinase |
| Clonality: | | Polyclonal |
| Immunogen: | | Synthetic peptide [KLH conjugated] made to the internal |
| CrossReactivity: | | Human. |
| Packaging: | | 0.05 ml of affinity purified sera in Phosphate buffered saline, PH 7.7 containing 0.01% sodium azide. |
| Uses: | | Immunohistochemistry with formalin fixed paraffin embedded tissues. The recommended dilution is 8 ug/ml. Not tested for other uses. |
| Background: | | TNIK is a MSN protein kinase that interacts with both TNF receptor-associated factor 2 (TRAF2) and the adapter protein NCK. The protein has been shown to activate the c-Jun N-terminal kinase pathway when overexpressed in Phoenix-A cells, and this activation is mediated solely by the C-terminal germinal center kinase homology region. TNIK has been shown to phosphorylate gelsolin, the principal intracellular and extracellular actin-severing protein, in vitro. This and evidence from mutational studies suggest that TNIK functions in the regulation of the cytoskeleton. At least eight splice isoforms have been reported. Northern analysis indicates TNIK expression in human heart, skeletal muscle, and brain, with lower levels of expression in kidney, liver, lung, and pancreas. ESTs have been isolated from human tissue libraries, including normal amnion, gallbladder, skin, and testis and cancerous bone, germ cell, nerve, and placenta. |
| Storage: | | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | | Peptide affinity purified |
| Host_Name: | | Rabbit |
| ListPrice: | | 325 |
| AppSummary: | | IHC-Fr, IHC-P |
| SpeciesSummary: | | Hu |
| ALTnames: | | anti-TNIK antibody |
| ProteinTarget: | | Traf2 And NCK-Interacting Kinase |
| PackageSize: | | 0.05 ml |
| NotesMain: | | Genbank accession number: AB011123 |
| more information: | | company product webpage |
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