| CatalogCode: | NLS7186 |
| ProductName: | Macrophage-Stimulating 1 Receptor Antibody |
| Product Description: | Rabbit Polyclonal anti-Macrophage-Stimulating 1 Receptor |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide [KLH conjugated] made to the C-term |
| CrossReactivity: | Human. 88% identity and 100% homology to mouse. |
| Packaging: | 0.05 ml peptide affinity purified Rabbit antisera. |
| Uses: | Not tested for other uses. |
| Background: | MST1R/Ron, a HGF Receptor/MET-type protein kinase, mediates the biological activities of macrophage-stimulating protein (MSP), a multifunctional cytokine that regulates cell adhesion, motility, growth, and survival. The protein is a membrane-spanning, disulfide-linked heterodimer, which results from cleavage of a glycosylated precursor into 35-kD (alpha) and 150-kD (beta) subunits. Ligand binding results in tyrosine phosphorylation of the beta chain. In knockout studies, MST1R/RON (-/-) mice failed to survive past the periimplantation period. The MST1R/RON gene has been mapped to 3p21, a region of frequent deletion or mutation in small cell lung and renal carcinoma, and has been implicated in the progression of several epithelial cancers. MST1R/Ron expression has been documented in many normal human tissues. ESTs have been isolated from several tissue libraries, including normal colon, mouth, prostate, and testis and cancerous colon, prostate, stomach, and uterus. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | peptide affinity purified |
| Host_Name: | Rabbit |
| ListPrice: | 375 |
| AppSummary: | IHC-P |
| SpeciesSummary: | Hu |
| ProteinTarget: | Macrophage-Stimulating 1 Receptor |
| PackageSize: | 0.05 ml |
| NotesMain: | Genbank accession number: NM_002447 |
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