| CatalogCode: | NLS6005 |
| ProductName: | Nuclear Receptor Rev-ErbA Alpha Antibody |
| Product Description: | Rabbit Polyclonal anti-Nuclear Receptor Rev-ErbA Alpha |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide conjugated to KLH |
| Specificity: | internal domain of human |
| CrossReactivity: | Human, mouse, Monkey. 94% identity and 100% homology in rat. |
| Packaging: | 0.05 ml Immunogen affinity purified Rabbit antisera. |
| Localization: | Nuclear |
| Background: | Rev-erbA alpha, a NR1 Thyroid Hormone-Like Receptor, is encoded by the same genomic locus as, but transcribed from the opposite strand of, Thyroid Hormone Receptor Alpha (TR Alpha). Rev-erbA alpha is a target of Nuclear Receptor ROR Alpha (Delerive et al. 2002), and a transcription regulator that has been shown to affect myocyte differentiation, adipogenesis, and lipoprotein metabolism. Recently Reb-erbA alpha has been shown to affect circadian rhythms by regulating cyclic Bmal1 transcription (Preitner et al. 2002, Ueda et al. 2002). Mice lacking Rev-erbA alpha show abnormal postnatal cerebellar development. Rev-erbA alpha expression has been documented in human skeletal muscle and a variety of mouse and rat tissues. ESTs have been isolated from human tissue libraries, including cancerous adrenal, blood, brain, breast, colon, duodenum, fetus, head/neck, kidney, lung, skeletal muscle, skin, synovium, and uterus, and normal brain, breast, colon, eye, heart, pancreas, pituitary, rostate, skeletal muscle, skin, testis, and thyroid. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Immunogen affinity purified |
| Host_Name: | Rabbit |
| Buffer: | Phosphate buffered saline, PH 7.7 |
| ListPrice: | 325 |
| AppSummary: | IHC-P |
| SpeciesSummary: | Hu, Mu, Mk |
| ALTnames: | anti-ERBA-RELATED 1 antibody; anti-Nuclear Receptor Rev-ErbA Alpha antibody; anti-Nuclear receptor subfamily 1 group D member 1 antibody; anti-Orphan nuclear receptor NR1D1 antibody; anti-REV-ERBalpha antibody; anti-THRA1 antibody; anti-THRAL antibody; anti-Thyroid hormone receptor alpha-like antibody; anti-V-erbA related protein EAR-1 antibody |
| ProteinTarget: | Nuclear Receptor Rev-ErbA Alpha |
| PackageSize: | 0.05 ml |
| NotesMain: | Genbank accession number: NM_021724 |
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