| CatalogCode: | | NLS56 |
| ProductName: | | Endothelin B Receptor Antibody |
| Product Description: | | Rabbit Polyclonal anti-Endothelin B Receptor |
| Clonality: | | Polyclonal |
| Immunogen: | | N-terminal extracellular domain of human |
| CrossReactivity: | | Human |
| Packaging: | | 0.05 ml |
| Uses: | | Immunohistochemistry of Formalin fixed paraffin embedded sections. Suggested starting dilution is |
| Background: | | The Endothelin Receptor ETB is expressed in most tissues. Mutations of the receptor gene are responsible for Hirschsprung disease type 2, a multigenic disorder with phenotypes such as bicolored irides, megacolon, hypopigmentation, and hearing loss. The ETB receptor has similar affinity for all three endothelins and activates a phosphatidylinositol-calcium second messenger system. A splice variant, termed SVR, has been described; the sequence of the ETB-SVR receptor is identical to ET-B receptor, with the exception of the intracellular C-terminal domain. While both splice variants bind endothelin ET1, they exhibit different responses, which suggests that they may be functionally distinct. The endothelin B receptor has been reported to be expressed in adrenal, aorta, artery, brain, breast, eye, epididymis, ganglion, heart, kidney, liver, lung, ovary, placenta, prostate, skin, testis, uterus, and vessel. ESTs have been isolated from amnion, B-cell/lung/testis, breast, brain, colon, ear, embryo, eye, heart, kidney, liver, liver/spleen, lung, lymph node, placenta, prostate, and skin libraries. |
| Storage: | | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | | Peptide affinity purified |
| Host_Name: | | Rabbit |
| Buffer: | | Phosphate buffered saline, pH 7.7, containing 0.01% sodium azide |
| ListPrice: | | 325 |
| AppSummary: | | IHC-P |
| SpeciesSummary: | | Hu |
| ALTnames: | | anti-Ednra antibody, anti-Ednrb antibody, anti-Endothelin B receptor precursor antibody, anti-Endothelin receptor type B antibody, anti-ETB antibody, anti-Hirschsprung disease 2 antibody, anti-HSCR antibody, anti-HSCR2 antibody |
| ProteinTarget: | | Endothelin B Receptor |
| PackageSize: | | 0.05 ml |
| more information: | | company product webpage |
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